The group of molecular tools for living system studies

Department of functioning of living systems

Head: Andrey Aralov

RNA, DNA, G-quadruplex, i-motif, antisense oligonucleotides, probes, pH sensors, modification, fluorescence

The main research areas of the group include:

  • design and synthesis of nucleotide modifications for fine tuning the properties of canonical and non-canonical secondary nucleic acids structures;
  • development of nucleotide modifications suitable for antisense and RNAi technologies for regulating gene expression;
  • synthesis and screening of probes/ligands for detecting and fine tuning physicochemical parameters of noncanonical secondary nucleic acids structures; 
  • development and study of the properties of metal-binding modifications within oligonucleotides;
  • study of the physicochemical properties of modifications that arise in living organisms when exposed to mutagenic factors; 
  • design and synthesis of antiviral compounds.
Andrey Aralov, Ph.D.s. r. f.
Alexey Chistovj. r. f.
Polina Kamzeevaj. r. f.

Andrey Aralov

Russia, Moscow, Ul. Miklukho-Maklaya 16/10 — On the map