Human SRD5A1 as a case of gene expression indel-resistance in triple-coding region
Theoretically, any nucleotide sequence can be translated in three reading frames, resulting in three different polypeptides. However, so far, only dual coding natural mRNAs have been found. A group of researchers from IBHh, University College Cork and other institutes have discovered a unique case of triple coding in the SRD5A1 gene. In this gene, translation initiation occurs on three closely spaced AUG codons within three reading frames. Depending on the splicing, translation from one of the three start codons leads to the synthesis of a protein with a catalytic domain. The unusual architecture of the gene makes it possible not to lose the expression of a protein with a catalytic domain in case of indel mutations. This work is published in Genome Biology.
july 20