Institute of
bioorganic chemistry

Researchers from the Department of Genomics and Postgenomic Technologies at the State Research Center Institute of Bioorganic Chemistry of the Russian Academy of Sciences and the Department of Regenerative Medicine at Pirogov Russian National Research Medical University have shown that the ag1 gene, an important regulator of regeneration in amphibians that was lost in all amniotes, including reptiles, birds, and mammals, during evolution, can accelerate skin wound healing when introduced into the mouse genome. Activation of this gene in transgenic mice was found to trigger molecular programs associated with regeneration-biased and scar- reduced tissue repair. These findings open new perspectives for fundamental research in tissue regeneration and repair. The results are published in Frontiers in Cell and Developmental Biology. Learn more

Viruses often use non-standard mechanisms to translate their mRNAs, which makes it possible to suppress the translation of cellular mRNAs and capture the entire cellular translation apparatus for the synthesis of viral proteins. In a paper published in Nucleic Acids Research, the authors from IBCh and colleagues from the Justus Liebig University (Germany) found that picornaviruses from the genus of cardioviruses (for example, encephalomyocarditis virus, EMCV) have two structures similar to glycyl tRNA in the 5’ and 3’ untranslated regions of mRNA. It has been shown that these elements bind glycyl tRNA synthetase (GARS), and this is necessary for efficient translation of viral mRNA. The interaction of the GARS dimer with 5’ and 3'HTO is likely to cause mRNA cyclization.

Researchers from the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, MEPhI, the Kurchatov Institute, and Uppsala University have developed a novel nanoparticle system for the effective delivery of rifampicin to the lungs. Using metal-organic frameworks (MOFs) with a MIL-101(Cr) structure, the team achieved high antibiotic loading and sustained release, offering a potential breakthrough in treating bacterial lung infections, including tuberculosis. The study was published in the journal Biomedical Materials. Learn more

The Group of Molecular Ecology, in close cooperation with scientists from some Pushchino Institutes, has for the first time obtained experimental data on the supramolecular structure of natural humic substances using a set of original techniques. It has been established that various types of morphological supramolecular nanostructures are associated with a certain chemical composition and various ecological and biogeochemical functions of humic substances. The work was published in the prestigious scientific journal Chem. Biol. Technol. Agric., IF-5.2, Q1 (Springer Nature publishing house).

Using Raman spectroscopy, a comparative analysis of venoms from various animals and a number of substances of different nature (not-venoms) was carried out. Animal venom smuggling is a global problem. It is often impossible to prove that the smuggled material is an animal venom. Raman spectroscopy can be used to implement a quick and simple method for identifying dry animal venoms. We demonstrated that Raman spectroscopy combined with principal component analysis (PCA) can distinguish between crude venom and not-venom samples, as well as cluster different animal venoms based on their similarities. The proposed method appears promising for on-site venom identification, for example, at border controls. Learn more