
Impact of Exogenous Application of Potato Virus Y-Specific dsRNA on RNA Interference, Pattern-Triggered Immunity and Poly(ADP-ribose) Metabolism in Potato Plants
Methods for inhibition of viral infection induced by spraying plants with preparations of specific double-stranded RNAs (dsRNAs) are currently being actively developed. Researchers from the Laboratory of functional genomics and plant proteomics, the Laboratory of Molecular Diagnostics and the Laboratory of Molecular Bases of Plant Stress Resistance of the Institute of Bioorganic Chemistry RAS studied the contribution of potato plant treatment with dsRNA against potato virus Y (dsRNA-PVY) to two dsRNA-induced plant defense mechanisms: specific RNA interference (RNAi) and non-specific pattern-triggered immunity (PTI). It has been shown that application of PVY dsRNA in potato plants induced accumulation of both small interfering RNAs (siRNAs), a hallmark of RNAi, and some gene transcripts related to PTI. The results are published in the International Journal of Molecular Sciences. Learn more
News 
- Impact of Exogenous Application of Potato Virus Y-Specific dsRNA on RNA Interference, Pattern-Triggered Immunity and Poly(ADP-ribose) Metabolism in Potato Plants
science news
VIII.15 Methods for inhibition of viral infection induced by spraying plants with preparations of specific double-stranded RNAs (dsRNAs) are currently being actively developed. Researchers from the Laboratory of functional genomics and plant proteomics, the Laboratory of Molecular Diagnostics and the Laboratory of Molecular Bases of Plant Stress Resistance of the Institute of Bioorganic Chemistry RAS studied the contribution of potato plant treatment with dsRNA against potato virus Y (dsRNA-PVY) to two dsRNA-induced plant defense mechanisms: specific RNA interference (RNAi) and non-specific pattern-triggered immunity (PTI).
- SOX9 Protein in Pancreatic Cancer Regulates Multiple Cellular Networks in a Cell-Specific Manner
science news
VIII.12 Pancreatic ductal adenocarcinoma is one of the most lethal cancers worldwide. Sex-determining region Y-box protein 9 (SOX9) is upregulated in the majority of pancreatic ductal adenocarcinoma cases. It is hypothesized that the increased expression of pancreatic developmental factor SOX9 is necessary for the formation and maintenance of tumor phenotypes in pancreatic cancer cells.
- Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors
science news
VII.19 Both ganglioside GD2-specific immunotherapy and antibody-drug conjugates (ADCs), as a class of targeted drugs, have demonstrated clinical success as solid tumor therapies in recent years, yet practically no research has been carried out on ADCs directed to ganglioside GD2. In a new study, scientists from the Department of immunology at IBCh RAS in collaboration with colleagues from other Russian institutes for the first time show that clinically relevant anti-GD2 antibody-drug conjugates manifest potent and highly selective cytotoxicity in a wide panel of cell lines with varying GD2 expression and strongly inhibit tumor growth in mouse models of GD2-positive solid cancer.
Events 
- Seminar “Molecular brain”: Allan Kalueff
science news
V.12 (This event is over) Seminar “Molecular brain” resumes its work after the long delay caused by pandemic of new coronavirus infection. However, all the people who are liking to listen lectures on-line, can participate via zoom-translation (link). The seminar will be held on the 12th of May at 3 pm in the Small lecture hall (3rd floor, BON, IBCh). Everyone is welcome!
- Gene therapy 2.0: AAV beyond monogenic gene correction
science news
II.4–5 (This event is over) Founding and managing partner of 4BIO Capital - Dmitry Kuzmin - will make a presentation in conference room 04 Februry 2022 at 15:00