The new method for T-cell receptor alpha chain clonality assessment can be used for minimal disease monitoring in leukemia
A group of scientists from Laboratory of Comparative and Functional Genomics in collaboration with colleagues from Masaryk universities and Dmitry Rogachaev center for pediatric hematology, oncology and immunology developed a method for clonality assessment of human T-cell receptor alpha chain gene rearrangements. They showed for the first time that such rearrangements are found in approximately 50% of the tumors of patients with various oncohematological malignancies. The new method will improve minimum residual disease monitoring for the treatment of leukemia. Results of the study are published in British Journal of Haematology. Learn more
december 27, 2019