Molecules, 2022, 27(24):9060

Ratiometric Singlet Oxygen Sensor Based on BODIPY-DPA Dyad

Compounds sensitive to reactive oxygen species are widely used in the study of processes in living cells and in the development of therapeutic agents for photodynamic therapy. In the present work, we have synthesized a dyad in which the BODIPY dye is chemically bound to 9,10-diphenylanthracene (DPA). Here, DPA acts as a specific sensor of singlet oxygen and BODIPY as a reference dye. We studied the photophysical properties of the BODIPY-DPA dyad and showed that energy transfer occurs between the chromophores. As a result, the compound has excitation maxima in the absorption region of both DPA and BODIPY, but the fluorescence emission occurs mainly from BODIPY. In the presence of singlet oxygen, the excitation maximum of DPA decreases, while the intensity of the excitation maximum of BODIPY remains almost unchanged. This allows the BODIPY-DPA dyad to be used as a ratiometric sensor of singlet oxygen.

Pakhomov AA, Belova AS, Khchoyan AG, Kononevich YN, Ionov DS, Maksimova MA, Frolova AY, Alfimov MV, Martynov VI, Muzafarov AM

IBCH: 10396
Ссылка на статью в журнале: https://www.mdpi.com/1420-3049/27/24/9060
Кол-во цитирований на 07.2026: 5
Данные статьи проверены модераторами 2022-12-24

Список научных проектов, где отмечена публикация

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