Bull Exp Biol Med, 2025

Specific Matrix on the Basis of Angiotensin-Converting Enzyme 2: Development and Functional Analysis

In this study, an affinity matrix based on recombinant human angiotensin-converting enzyme 2 (ACE2) immobilized on a porous polymeric substrate was developed and characterized. The matrix efficiently binds viral particles pseudotyped with the SARS-CoV-2 spike protein. These findings highlight the prospects for creating novel affinity matrices for extracorporeal hemoperfusion aimed at reducing viral load in patients with high viremia and severe COVID-19.

Kostin NN, Bobik TV, Rushkevich NY, Skryabin GA, Kaliberda EN, Knorre VD, Smirnov IV, Gabibov AG

Department of Peptide and Protein Technologies, Laboratory of biocatalysis, Laboratory of proteolytic enzyme chemistry

: 10.1007/s10517-025-06463-2
Scopus: 2-s2.0-105014446578
: 40875099
IBCH: 12086
Ссылка на статью в журнале: https://link.springer.com/10.1007/s10517-025-06463-2
Нет данных о цитировании
Данные статьи проверены модераторами 2025-10-19

Список научных проектов, где отмечена публикация

  1. Development of means of prevention and treatment of COVID-19 and concomitant infectious diseases using genetic technologies (September 28, 2021 — December 31, 2023). Gabibov A.G., Andreev D.E., Aralov A.V., Bezuglov V.V., Belogurov A.A., Vodovozova E.L., Zvyagin A.V., Konstantinova I.D., Korshun V.A., Ovchinnikova T.V., Rubcov Y.P., Smirnov I.V., Tonevickiy A.G.. Agreement / contract, Ministry of Science.