DNA methylation of the (Elongation of Very Long Chain Fatty Acids Protein 2) promoter is one of the most robust molecular biomarkers for chronological age; however, whether plays a functional role in brain aging and immunosenescence, and whether the genotype modulates these effects, has not been fully explored. This study investigated the associations among 2 methylation, genotype, and neurophysiological changes in the brain, as well as indicators of immunosenescence of peripheral blood T cells during aging.