Previous studies have shown that Heliox, a mixture of 32% oxygen and 68% helium administered at a warm temperature, is effective in treating ischemic brain injury caused by cerebral arterial air embolism. At the same time, therapeutic hypothermia has been shown to lead to a favorable neurological outcome in patients in the acute phase of ischemic stroke; however, there are no published data on the use of Heliox at room temperature after ischemic stroke. All published data indicate only the efficacy of heated Heliox. The most effective temperature regimen for Heliox inhalation to prevent neurological deficits in stroke remains unknown.