Russ. J. Bioorganic Chem., 2020, 46(3):315-320

5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses.

In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); and human respiratory syncytial virus (RSV). Related known compounds were also analyzed: 5-(perylen-3-ylethynyl)-2′-deoxy-uridine; 5-(perylen-3-ylethynyl)-arabino-uridine; and 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil.

Nikolayeva YV, Ulashchik EA, Chekerda EV, Galochkina AV, Slesarchuk NA, Chistov AA, Nikitin TD, Korshun VA, Shmanai VV, Ustinov AV, Shtro AA

Laboratory of molecular design and synthesis

: 10.1134/S1068162020030139
Scopus: 2-s2.0-85087065539
: 32834709
IBCH: 8738
Ссылка на статью в журнале: http://link.springer.com/10.1134/S1068162020030139
Кол-во цитирований на 02.2025: 10
Данные статьи проверены модераторами 2020-09-01

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