Bull Exp Biol Med, 2012, 153(3):371-374

Effect of delta sleep-inducing peptide on oxidative modifi cation of proteins in rat tissues and blood during physiological aging

Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleenmyocardium testiclesliverskeletal muscles) has been demonstrated. Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specifi c. Delta sleep-inducing peptide exhibited a hypoglycemic effect: it prevented nonenzymatic glycosylation of hemoglobin and reduced the level of defective protein molecules during aging. © 2012 Springer Science+Business Media, Inc.

Bondarenko TI, Sorokina IA, Mayboroda EA, Durkanaeva OA, Kutilin DS, Mikhaleva II

IBCH: 4676
Ссылка на статью в журнале: http://link.springer.com/10.1007/s10517-012-1719-3
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