The molecular mechanism of redox interaction between neuroglobin and cytochrome c
Neuroprotective activity of neuroglobin (Ngb) is presumably based on its redox interaction with cytochrome c (Cyt c), the mechanisms of which have not yet been elucidated. Authors developed a new methodological approach to study the electron transfer between heme proteins based on Raman spectroscopy. We studied the conformational changes in the Cyt c heme and the effect of the protein microenvironment of Cyt c and Ngb hemes on electron transfer between them using developed approach. Obtained data allowed us to propose a step-by-step mechanism of interaction between Ngb and Cyt c. Understanding the mechanisms of interaction between Ngb and Cyt c is necessary for future practical applications related to the therapy of neurodegenerative diseases. The results are published in the International Journal of Biological Macromolecules. Learn more
12 июня