Gastric cancer (GC) remains one of the most common lethal diseases. Every year, about 1 million people fall ill and almost 800 thousand people die worldwide1. Surgical treatment has reached its limit. The current advances in immunology and detection of epidermal growth factor molecules (EGFR) in gastric cancer cells allowed to improve the treatment results; however, the metastatic form of this disease is still incurable.In recent years researchers have focused attention on mannose (D-Man), a hexose which is an essential component of all glycoprotein N-chains involved in normal physiologic and pathologic processes. Man is recognized by mannose-binding lectin (MBL) and the mannose receptor (MR), which is expressed in dendritic cells and macrophages.