Acid-sensing ion channels (ASICs) are proton-gated cation channels that belong to the degenerin–epithelial sodium channel (DEG/ENaC) family. In mammals, at least six subunits (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4) have been identified, forming homo- and heterotrimeric complexes with distinct proton sensitivity, channel kinetics and responsiveness to various positive and negative modulators. Among them, ASIC1a and ASIC3 are particularly significant due to their high pH sensitivity. ASIC3 channels exhibit faster desensitization kinetics and are capable of generating a sustained current component that follows the transient component [1,2]. ASICs are expressed in both central and peripheral sensory neurons, where they are implicated in various physiological and pathological processes, such as synaptic plasticity, fear conditioning, learning, memory, ischemic stroke, neurodegeneration, nociception, inflammatory processes, tumor development, mechanical hyperalgesia and myocardial ischemia [3,4].