Being laboratory head, Yuri Lebedev proceeds with his research on interaction of retroelements and primate genome and evolves his efforts in related fields of functional genomics. Dr. Lebedev is the first (or leading) author of over 60 articles and reviews. In addition to basic research he carries out education of students as a permanent speaker at schools for young scientists as well as a supervisor of student’s projects. During the last 10 years, under Dr. Lebedev supervision over 20 masters of sciences together with 7 PhDs have been graduated from his group.
Dr. Lebedev became the winner of A.A. Baev prize rewarded “for series of research on high-resolution mapping of transcribed and regulatory sequences on Chr19” in 1997.
Dr. Lebedev is one of the leading Russian scientists working in the field of mammalian genome structure, functioning and evolution. He started research in the field in the early nineties. Since establishing Russian State program “Human Genome”, Dr. Lebedev with other young scientists from Eugene Sverdlov’s lab joined the program among the first participants. In these years Yuri Lebedev’s research was focused on functional mapping of distinct human chromosomes.
Being presented at several HUGO Meetings, Dr. Lebedev’s results attracted a high interest of the specialists. As a part of his work on functional mapping of human chromosome 19, Dr. Lebedev published his first articles on the problem of HERV LTR’s impact on human genome evolution. Dr. Lebedev elaborated a concept of involvement of retroelement mobility in primate speciation. According to this theory retroposition of multiple regulatory sequences could result in essential modulations of gene expression systems. The first experimental genome-wide comparison of retroelement distribution in human and chimpanzee genome was performed under Dr. Lebedev’s supervision. The results of the project confirmed main postulates of Lebedev’s concept and led to discovery of representative groups of retroelements that present exclusively in human genome. Newly developed approach to mammalian genomes comparison and discovering of human specific retroelements were selected for annual issues of “The most important achievements of Russian Academy of Sciences” in 2001—2003 years. At the end of 2004, Dr. Lebedev defended his doctoral thesis entitled “Human endogenous retroviruses: structural-evolutionary analysis”.