The main scientific interests of Dr. Zaraisky are focused on structural and functional study of genes and proteins that regulate embryonic development of the brain.
Under the leadership of Dr. Zaraisky in the laboratory of molecular bases of embryogenesis a novel class of homeobox genes, Anf, was discovered and studied. These genes encode for the homeodomain transcription factors, which play a key role in regulation of the early forebrain development in Vertebrates. Further investigation of the gene network related to the functioning of Anf led to the discovery of a novel, the 8th, a family of small GTFases, named as Ras-dva, which are specifically expressed in the forebrain rudiment and regulate its early development. An important achievement of the laboratory of molecular bases of embryogenesis is discovering of two novel families of secreted proteins, Noggin2 and Noggin4, whose genes are controlled by Anf homeodomain factors. These novel representatives of Noggin proteins are able to bind and thereby inhibit a number of growth factors of the TGF-β superfamily.
Scientific societies’ membership
Dr. Zaraisky is a member of the Academic and Dissertation councils of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Editorial Boards of the journals Molecular Biology and Russian Journal of Developmental Biology.