Laboratory of regulatory transcriptomics

Department of Genomics and Postgenomic Technologies

Head: Tatyana Azhikina

transcriptomics of Mycobacteria, dormancy, latency, small noncoding RNAs, regulation of expression in bacteria, antibacterial agents, epigenetics, piRNA/PIWIL system, tumorigenesis, circulating DNA, epigenetic markers

Laboratory of regulatory transcriptomics is doing fundamental research in molecular biology, molecular microbiology, epigenetics and molecular oncology. The laboratory studies regulatory functions of RNA in both pro- and eukaryotes. Regulatory role of bacterial non-coding RNAs in tuberculosis is being studied. Investigation of regulation of ribosomal proteins genes in bacteria, including mycobacteria, are being carried out.

Other directions: identifying the detailed mechanisms of the functioning of piRNAs and PIWIL proteins in testicular tumors, and analysis of epigenetic patterns of circulating blood DNA in cancer.

Methods of molecular biology, genetic engineering, microbiology, molecular genetics,  high-throughput sequencing and bioinformatic approaches are actively used.

The laboratory cooperates with many laboratories and groups of the IBCh, as well as the Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences (laboratory of biochemistry of stresses in microorganisms, headed by Prof. Arseny Kaprelyants), Central Research Institute for Tuberculosis (laboratory of immunogenetics, headed by Prof. Alexander Apt), N.N. Blokhin Russian Cancer Research Center, Research Institute of Oncology of the Tomsk National Research Medical Center, Institute of Chemical Biology and Fundamental Medicine of the SB RAS.

International contacts - Institut de Biologie Physico-Chimique, Paris Diderot University, France.




Tatyana Azhikina

Russia, Moscow, Ul. Miklukho-Maklaya 16/10 — On the map