Nursery for laboratory animals

Branch of the Institute (Pushchino)

Head: Georgij Telegin, Ph.D.
telegin@bibch.ru,  +7(4967)33-05-57#3122

www.spf-animals.ru/

Groups in the department: Veterinary Service

SPF-animals

NamePositionContacts
Georgij Telegin, Ph.D.headtelegin@bibch.ru,  +7(4967)33-05-57#3122

All publications (show selected)

Loading...

Georgij Telegin

  • Russia, Moscow, Ul. Miklukho-Maklaya 16/10 — On the map
  • IBCh RAS, build. "Питомник лабораторных животных ФИБХ", office.
  • Phone: +7(4967)33-05-57#3122
  • E-mail: telegin@bibch.ru

Fax: +7 (4967) 33-05-57

Customer relationship manager

Elena V. Malyavina

Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment.

In collaboration with Laboratory of molecular immunology

For the first time, a strategy of regiospecific targeting the same receptor of two antitumor toxins with different mechanisms of action – the antibiotic doxorubicin in targeted  nanoparticles with diagnostic fluorescent die and protein targeted toxin - has been developed for the enhanced image-guided cancer treatment. A strong synergistic effect of these toxins on the tumor has been shown, which makes it possible to reduce the effective doses of toxins by 1000 times in in vitro experiments and significantly improve the therapeutic effect in vivo.

Publications

  1. Shipunova VO, Komedchikova EN, Kotelnikova PA, Zelepukin IV, Schulga AA, Proshkina GM, Shramova EI, Kutscher HL, Telegin GB, Kabashin AV, Prasad PN, Deyev SM (2020). Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano ,

Development of new approaches to the creation of experimental animal biomodels of socially significant pathological conditions in humans and cryopreservation of genetic resources as required of AAAALAK International and ISO

The model of structured precision spinal cord injury at rats of SPF-category was verified. An application has been prepared for obtaining the priority intellectual property right “Method of modeling the glial scar - the original use of cryodestruction of glial tissues” and “Tool for modeling of glial scar on the spinal cord of rats - cryoapplicator”. New species of animals added to the collection of genetic bioresources of the Animal breeding facility BIBCH RAS - the laboratory rabbits NZW SPF-category, from breeding facility of Envigo (Israel). The system of management of production of small laboratory rodents of SPF category is successfully recertified SGS United Kingdom Ltd as meeting the requirements of ISO 9001:2015.

Development of new approaches in creation and cryopreservation of genetically modified animals biomodels according to requirements of AAALACi and ISO

The Cryobank collection of  Animal breeding facility due to preservation of genetically modified lines of mice, unique for Russia, is expanded. The Standard of Organization «Cryopreservation of Genetic Resources» is developed and formalized.The model of the structured spinal cord injury at rats of SPF category is developed. The system of management of production of small laboratory rodents of SPF category is successfully recertified SGS United Kingdom Ltd as meeting the requirements of ISO 9001:2015.

Publications

  1. Minakov AN, Chernov AS, Asutin DS, Konovalov NA, Telegin GB (2018). Experimental Models of Spinal Cord Injury in Laboratory Rats. Acta Naturae 10 (3), 4–10
  2. Barykin EP, Petrushanko IY, Kozin SA, Telegin GB, Chernov AS, Lopina OD, Radko SP, Mitkevich VA, Makarov AA (2018). Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition. Front Mol Neurosci 11, 302
  3. Kozin SA, Barykin EP, Telegin GB, Chernov AS, Adzhubei AA, Radko SP, Mitkevich VA, Makarov AA (2018). Intravenously injected amyloid-β peptide with isomerized Asp7 and phosphorylated Ser8 residues inhibits cerebral β-amyloidosis in AβPP/PS1 transgenic mice model of Alzheimer's disease. Front Neurosci 12 (AUG), 518

Design and development, breeding, maintenance and supply of small laboratory rodents of SPF category according to the international requirements of AAALACi and ISO

The AAALAC International Council on accreditation reports that the program of Animal Breeding Facility BIBC RAS conforms to the AAALAC International standards explained by the Guide for the Care and Use of Laboratory Animals NRC 2011), confirm FULL ACCREDITATION shall continue. Especially noteworthy were enthusiasm attending veterinarian and of personnel who were open and helpful in answering questions and providing information and also a high level of maintenance of the facility and good welfare status of the animals.

The system of management of production of small laboratory rodents of SPF category is successfully recertified SGS United Kingdom Ltd as meeting the requirements of ISO 9001:2008.

Other files

Отчет о НИР
pdf, 5.19 MbMarch 5
Инвентаризация и развитие биоресурсной коллекции лабораторных грызунов (заключительный)