The secret of fireworm is out: molecular basis of Odontosyllis bioluminescence
Bioluminescence – a widespread in the natural world process of “cold light” emission by living organisms, is based on an enzyme-dependent biochemical oxidation reaction in which energy is released in the form of light. Out of 40 presumed bioluminescent systems only for nine the structures of substrates - luciferins were elucidated, while a complete description of the luciferin biosynthesis pathway along with the corresponding enzymes was done only for two. A collaborative effort by an international team of scientists led to the discovery of new luciferin from marine polychaetes Odontosyllis undecimdonta. The characterization of three key low-molecular-weight components of Odontosyllis bioluminescence system, presented in an article published in the journal Proceedings of the National Academy of Sciences USA, further enabled the elucidation of the molecular mechanisms of bioluminescence of this organism. Learn more
- PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently emerged as a promising cancer drug target, and two PRMT5 inhibitors are currently in clinical trials for a range malignancies. Despite the recognized therapeutic potential, it is unclear which PRMT5 functions underlie its oncogenic activity.
- A previously unknown modulator of purinergic and FGF-signalization, c-Answer, that stimulates regeneration in cold-blooded animals was lost by poorly regenerating warm-blooded animals, including humans
A group of scientists from the Laboratory of Molecular Bases of Embryogenesis, IBCh RAS, together with colleagues from the Laboratory of Mathematical Methods and Models in Bioinformatics, IPPI RAS developed a bioinformatics method that allows one to reveal genes that appear or disappear at a certain stage of evolution. Using this method, a number of genes were found that disappeared in warm-blooded animals, including humans.
- Peptides encoded by short open reading frames regulate plant growth and development
All genomes contain millions of short open reading frames (<100 codons) that are discarded during genome annotation. Recently, it has been shown that peptides encoded by short open reading frames can perform many important functions in animal cells.
- LIGHTS ON: Molecular Imaging of disease dynamics in vivo
IX.27 X.11 (This event is over)
Abhijit De PhD Scientific Officer ‘F’ and Principal Investigator Head, Molecular Functional Imaging Lab Advanced Centre of Training Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.
- Seminar "Molecular Brain": Anton Maximov
X.8 (This event is over)
The seminar will be held on the 8th of October at 3 pm in the Small lecture hall (3rd floor, BON, IBCh). Everyone is welcome!
- II Joint Life Sciences Forum: VI Russian Congress on Biochemistry and IX Russian Symposium «Proteins and Peptides»
X.1–6 (This event is over)
Dear Colleagues! We are pleasure to invite you to participate the VI Russian Congress on Biochemistry, which will be held in Sochi, Russia (Dagomys Hotel) on October 1-6, 2019.