Transcription factor Foxp1 plays important role in Treg
Regulatory T cells (Treg) is subpopulation of T helper lymphocytes which possesses immune suppressive properties. Treg are critical in protection from excessive immune response and autoimmunity. Unique functions of Treg are defined by transcription factor Fop3 that controls Treg-specific expression of genes. Dr. Yury Rubtsov from the Dept. of functioning of living systems in cooperation with colleagues from the Memorial Sloan-Kettering Cancer Center (New York City) studied a role of Foxp3-related protein, Foxp1, specifically in the murine Treg. In the absence of Foxp1, Treg displayed distorted Foxp3 chromatin binding which led to decreased sensitivity of the cells to IL-2 and diminished suppressive capacity. Results of the study are published in Nature Immunology.
- Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T cell
Efficient and specific removal of malignant cells is the ultimate goal of cancer therapy. The current rapid development of chimeric antigen receptor T cell (CAR-T cell or CART) therapy potentially provides high efficiency and allows long-term surveillance, which have greatly extended the frontier of leukemia treatment.
- Nobel Prize winner, Arieh Warshel took part in the meeting of the IBCh RAS scientific council and joined the international advisory Board of the Institute
April 3rd 2019, a regular meeting of the IBCh RAS Scientific Council took place, featuring the 2013 Chemistry Nobel Prize awardee, Arieh Warshel. The scientist delivered a short talk, regarding the prospects of contemporary science and possibilities of using the quantum mechanics calculations to predict the behavior of complex systems, up to the organs and organisms. Director of our Institute, Alexander Gabibov, announced that professor Warshel had joined the International Advisory Board of the Institute, along with several other distinguished scientists, and presented him a symbolical gift.
- Scientists present a fully genetically encodable bioluminescent system
Scientists from Russia, UK, Spain, Brazil, Japan, and Austria discovered the essential set of enzymes that allows glowing fungi to emit light. The bioluminescent system includes a brand- new luciferase and three enzymes that enable biosynthesis of fungal luciferin from a widespread metabolite – caffeic acid – as well as its recycling. The genes encoding this “caffeic acid cycle” make up a unique molecular toolkit that allows to turn any higher organism into a glowing one. The work was published in Proceedings of the National Academy of Sciences of the United States of America.
- 12th INTERNATIONAL CONFERENCE “BIOCATALYSIS.FUNDAMENTALS & APPLICATIONS” “BIOCATALYSIS-2019”
Dear colleagues, The Lomonosov Moscow State University and RAS institutes, including IBCH RAS, is planning to convene a traditional biannual 12 th International Conference "BIOCATALYSIS-2019" in June, 24–28, 2019. Conference will be convened on board a ship cruising via the route St. Petersburg – Valaam – Kizhi – St. Petersburg. More info is available at http://bc2019.org/.
- Scientific School for young scientists «Structural biology: main problems and approaches to their solution»
Dear colleagues! The Scientific School is devoted to the latest achievements and methods in the field of structural research will be held at the IBCh RAS on Thursday, 6 June 2019. The scientific program of the School includes lectures by leading scientists working in various fields of molecular biology and representing the basic structural methods, namely, X-ray Crystallography, Cryo-Electron Microscopy, NMR-spectroscopy and computer modeling.
- "Molecular Brain" seminar
IV.16 (This event is over)
The seminar is timed to the birthday of academician Eugene Grishin and will take place on April 16 at 14:00 in the Hall of Academic Council. Members of the Department of Molecular Neurobiology created by Eugene, will give talks on their present work. Everyone is cordially invited.