In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors
The mononuclear phagocyte system (MPS) blockade improves the pharmacokinetics of diagnostic and therapeutic nanoparticles and reduces side toxicity. Scientists from MIPT, MEPhI, GPI and the Laboratory of molecular immunology of IBCh RAS studied the key factors that determine the effectiveness of the blockade: blocker particle dose, size, zeta potential and type of coating, as well as mouse strain, inflammation and the presence of a tumor. It was found that the type of blocker coating had the strongest effect on MPS blockade efficiency, which allowed to prolong circulation of functional nanoparticles in the bloodstream 18 times. The results obtained demonstrate the practical significance of the MPS blockade and possible mechanisms for its regulation to improve the delivery of diagnostic and therapeutic nanoagents. The work was published in the Journal of Controlled Release.
- Genomic DNA i-motifs as fast sensors responsive to near-physiological pH microchanges
Researchers from Federal Research and Clinical Center of Physical-Chemical medicine and Institute of Bioorganic Chemistry RAS, in collaboration with Skolkovo University of Science and Technology and D.Mendeleev University of Chemical Technology of Russia developed simple and robust sensors for detecting microchanges in intracellular pH.
- From cytoskeleton to pluripotency: a new mechanism for regulating stem status of the embryonic cells
Researchers from the Laboratory of Molecular Bases of Embryogenesis (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS), in technical cooperation with colleagues from the Department of Metabolism and Redox Biology (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS), the Laboratory of Genomics and Epigenomics of Vertebrates in the Federal Center "Fundamentals of Biotechnology" RAS, as well as with colleagues from the Cell Motility Group of the Institute of Protein Research RAS, discovered a previously unknown mechanism of the regulation of the activity of genes that determine the pluripotent status of the embryonic stem cells.
- Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape
Researchers of the Laboratory of Molecular Immunology, IBCh RAS, in collaboration with Russian colleagues have shown that the strategy of targeting of anticancer toxins to two different surface antigens on the surface of a cancer cell is effective in the treatment of not only primary solid tumors, but also distant metastases.
- International School "Molecular mechanisms of neurodegenerative diseases"
XI.26.20 (This event is over)
Moscow Institute of Physics and Technology (MIPT) invites you to take part in the International school for young scientists "Molecular mechanisms of neurodegenerative diseases", which will be held on November 26, 2020 online.
- Lipids 2021 Conference
Lipids 2021 Conference, October 19-21, 2021, IBCH RAS, Moscow
- Lecture by Director-General of the ICGEB Lawrence Banks «Human Papillomaviruses: From Infectious Entry to Malignancy»
I.27.20 (This event is over)
ICGEB Director-General Group Leader Lawrence Banks will deliver a lecture entitled «Human Papillomaviruses: From Infectious Entry to Malignancy». Date and time: Mon 27 January 2020 14:00. Location: Small conference hall at 3rd floor BON IBCh.