Group of bioengineering of neuromodulators and neuroreceptors
|Ekaterina Lyukmanova, Ph.D.||depart. firstname.lastname@example.org, |
|Mikhail Shulepko, Ph.D.||r. email@example.com, |
|Dmitrii Kulbatskii||j. r. firstname.lastname@example.org|
|Evgeny Loktyushov||j. r. email@example.com|
|Maxim Bychkov||j. r. firstname.lastname@example.org|
|Olga Shlepova||t. q. - lab. as.|
Mammalian three-finger proteins protect against cancer (2018-11-30)
The human secreted protein SLURP-1, which is expressed in epithelial cells and controls their proliferation and migration, has been found to inhibit the growth of epithelial cancer cells.
The effect of SLURP-1 on cancer cells is characterized by a positive feedback: exogenous (recombinant) SLURP-1 binds to α7 nicotinic acetylcholine receptors on the cell membrane and triggers a cascade of signals that activates secretion of endogenous SLURP-1 from intracellular depot, quickly increasing its concentration in the intercellular space and enhancing antiproliferative action.
Concentrations of SLURP-1, which suppress the growth of cancer cells, do not affect the growth of normal cells.
- (2018). Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors. Br J Pharmacol 175 (11), 1973–1986