Зацепина Ольга Владимировна

Доктор биологических наук


Руководитель подразделения (Лаборатория функциональной организации клеточного ядра)

Эл. почта: zatsepina_olga@mail.ru

Избранные публикации

  1. Moraleva A, Magoulas C, Polzikov M, Hacot S, Mertani HC, Diaz JJ, Zatsepina O (2017). Involvement of the specific nucleolar protein SURF6 in regulation of proliferation and ribosome biogenesis in mouse NIH/3T3 fibroblasts. Cell Cycle 16 (20), 1979–1991
  2. Lavrentyeva E, Shishova K, Kagarlitsky G, Zatsepina O (2017). Localisation of RNAs and proteins in nucleolar precursor bodies of early mouse embryos. Reprod Fertil Dev 29 (3), 509–520
  3. Shishova KV, Lavrentyeva EA, Khamidullina AI, Zatsepina OV (2016). Position of the nucleus in mouse germinal vesicle–stage oocytes with different chromatin configurations. RUSS J DEV BIOL 47 (6), 313–319
  4. Shishova KV, Khodarovich YM, Lavrentyeva EA, Zatsepina OV (2016). Data on morphology, large-scale chromatin configuration and the occurrence of proteins and rRNA in nucleolus-like bodies of fully-grown mouse oocytes in different fixatives. Data Brief 7 (0), 1179–1184
  5. Astafev AA, Zalesskiy AD, Zatsepina OV, Kostrov AN, Krivoharchenko AS, Osychenko AA, Serobyan GA, Nadtochenko VA (2016). Impact of tightly focused femtosecond laser pulses on nucleolus-like bodies of mouse GV oocyte and the ability of mouse oocytes to mature. Dokl Biochem Biophys 467 (1), 136–140
  6. Астафьев АА, Залесский АД, Зацепина ОВ, Костров АН, Кривохарченко АС, Осыченко АА, Серобян ГА, Надточенко ВА (2016). Воздействие остросфокусированного фемтосекундного лазерного излечения на ядрышкоподобное тельце GV ооцитов и способность ооцитов мыши к созреванию. 467 (5), 602–606
  7. Shishova KV, Khodarovich YM, Lavrentyeva EA, Zatsepina OV (2015). High-resolution microscopy of active ribosomal genes and key members of the rRNA processing machinery inside nucleolus-like bodies of fully-grown mouse oocytes. Exp Cell Res 337 (2), 208–218
  8. Shishova KV, Khodarovich YM, Lavrentyeva EA, Zatsepina OV (2015). Analysis of the localization of fibrillarin and sites of pre-rRNA synthesis in the nucleolus-like bodies of mouse GV oocytes after mild treatment with proteinase K. RUSS J DEV BIOL 46 (3), 127–136
  9. Станишевская ИЕ, Кордюкова МЮ, Владимирова НМ, Миронова АА, Станишевский ЯМ, Зацепина ОВ (2015). Перспективы использования протеомных бионаносистем в персонифицированной медицине. 1 (10), 60–63
  10. Шишова КВ, Ходарович ЮМ, Лаврентьева ЕА, Зацепина ОВ (2015). Анализ локализации фибрилларина и мест синтеза пре-рРНК в ядрышко-подобных тельцах GV ооцитов мыши после умеренной обработки протеиназой К. 46 (3), 162–173
  11. Shishova KV, Lavrentyeva EA, Dobrucki JW, Zatsepina OV (2015). Nucleolus-like bodies of fully-grown mouse oocytes contain key nucleolar proteins but are impoverished for rRNA. Dev Biol 397 (2), 267–281
  12. Fulka H, Kyogoku H, Zatsepina O, Langerova A, Fulka J (2015). Can Nucleoli Be Markers of Developmental Potential in Human Zygotes? Trends Mol Med 21 (11), 663–672
  13. Миронова АА, Барыкина НВ, Зацепина ОВ (2014). Цитологический анализ реакции ядрышковой РНК и РНК-связывающих белков на действие окислительного стресса в клетках HeLa. 56 (7), 489–499
  14. Кордюкова ЮМ, Ползиков МА, Шишова КВ, Зацепина ОВ (2014). Анализ белковых партнеров белка ядрышка человека SURF6 в клетках HeLa методом аффинной адсорбции. 40 (4), 1–12
  15. Кордюкова МЮ, Ползиков МА, Шишова КВ, Зацепина ОВ (2014). Функциональное значение белка ядрышка SURF6 человека – ключевого белка одноименного семейства эукариот. 455 (4), 1–3
  16. Kordyukova MY, Polzikov MA, Shishova KV, Zatsepina OV (2014). Functional significance of the human nucleolar protein SURF6, the key member of the SURF6 protein family in eukaryotes. Dokl Biochem Biophys 455 (1), 65–67
  17. Kordyukova MY, Polzikov MA, Shishova KV, Zatsepina OV (2014). Analysis of protein partners of the human nucleolar protein SURF6 in HeLa cells by a GST pull-down assay. Russ. J. Bioorganic Chem. 40 (4), 390–400
  18. Akhidova EV, Volkova TD, Koroev DO, Yakupov IY, Kalintseva MV, Zavalishina LE, Kaplun AP, Zharskaya OO, Zatsepina OV, Volpina OM (2013). Production of affinity purified antipeptide antibodies to survivin for structural and functional studies of the protein. Russ. J. Bioorganic Chem. 39 (3), 288–298
  19. Akhidova EV, Volkova TD, Koroev DO, Yakupov II, Kalintseva MV, Zavalishina LE, Kaplun AP, Zharskaia OO, Zatsepina OV, Volpina OM (2013). [Obtaining of the affinity purified antibodies against survivin for the structure functional study of the protein]. Bioorg Khim 39 (3), 326–337
  20. Красильщикова МС, Манских ВН, Арефьева АС, Зацепина ОВ (2013). Анализ реакции аутбредных мышей стока CFW на регулярные инъекции сублетальных доз хлорида ртути. 34 (2), 95–100
  21. Polzikov M, Yakovenko S, Voznesenskaya J, Troshina M, Zatsepina O (2012). Overexpression of ribosomal RNA in cumulus cells of patients with polycystic ovary syndrome. J In Vitro Fert Embryo Transf 29 (10), 1141–1145
  22. Barygina VV, Mironova AA, Zatsepina OV (2012). Parameters that affect estimation of nucleolar proteins' mobility in living cells by the FRAP method with the example of protein fibrillarin. Cell tissue biol 6 (2), 128–136
  23. Polzikov MA, Kordyukova MY, Zavalishina LE, Magoulas C, Zatsepina OV (2012). Development of novel mouse hybridomas producing monoclonal antibodies specific to human and mouse nucleolar protein SURF-6. Hybridoma (Larchmt) 31 (1), 48–53
  24. Барыгина ВВ, Миронова АА, Зацепина ОВ (2012). Параметры, влияющие на оценку подвижности белков ядрышка в живых клетках методом FRAP на примере белка фибрилларина. 54 (1), 17–24
  25. Costanzo M, Cisterna B, Zharskaya OO, Zatsepina OV, Biggiogera M (2011). Discrete foci containing RNase a are found in nucleoli of HeLa cells aged in culture. Eur J Histochem 55 (2), 82–84
  26. Kordyukova MY, Zatsepina OV, Polzikov MA (2011). Cloning, expression, and isolation from Escherichia coli of human protein SURF-6 translationally fused to glutathione-S-transferase. APPL BIOCHEM MICRO+ 47 (2), 123–127
  27. Barygina VV, ArefEva AS, Zatsepina OV (2010). The role of mercury in the processes of vital activity of the human and mammalian organisms. RUSS J GEN CHEM 80 (13), 2694–2703
  28. Malysheva MV, Grigoryev AA, Bulycheva TI, Zatsepina OV (2010). Enhanced sensitivity of nucleoli in human proliferating cells to inhibition of protein synthesis with anisomycin. Bull Exp Biol Med 150 (2), 258–262
  29. Arefieva AS, Dyban PA, Krasilshchikova MS, Dobrucki JW, Zatsepina OV (2010). Localization and composition of renal immunodeposits in mice developing HgCl2-Induced autoimmune process. Tsitologiia 52 (6), 477–486
  30. Arefieva AS, Dyban PA, Krasilshchikova MS, Dobrucki JW, Zatsepina OV (2010). Localization and Composition of Renal Immunodeposits in Mice Developing HgCl2-induced Autoimmune Process. Cell tissue biol 4 (4), 345–353
  31. Polzikov MA, Veiko NN, Zharskaya OO, Magoulas C, Zatsepina OV (2010). Overexpression of the nucleolar protein SURF-6 in mouse NIH/3T3 fibroblasts stabilizes pre-rRNA intragenic transcribed spacers. Russ. J. Bioorganic Chem. 36 (5), 610–619
  32. Barygina VV, Veiko VP, Zatsepina OV (2010). Analysis of nucleolar protein fibrillarin mobility and functional state in living HeLa cells. Biochemistry (Mosc) 75 (8), 979–988
  33. Sviridova-Chailakhyan TA, Zatsepina OV, Popov VI, Chailakhyan LM (2010). Ultrastructural analysis of pronuclei inactivated by local laser irradiation during mouse zygote enucleation. Dokl Biol Sci 431 (1), 162–165
  34. Rozhkova E, Yurinskaya M, Zatsepina O, Garbuz D, Karpov V, Surkov S, Murashev A, Ostrov V, Margulis B, Evgenev M, Vinokurov M (2010). Exogenous mammalian extracellular HSP70 reduces endotoxin manifestations at the cellular and organism levels. Ann N Y Acad Sci 1197 (0), 94–107
  35. Moraleva AA, Malysheva MV, Magoulas C, Polzikov MA, Zatsepina OV (2009). Early expression of nucleolar SURF-6 protein in mouse spleen lymphocytes activated for proliferation in vitro. Bull Exp Biol Med 147 (5), 578–582
  36. Glinka EM, Andryushchenko AS, Sapozhnikov AM, Zatsepina OV (2009). Construction of the plasmid for expression of ETA-EGFP fusion protein under control of the cytomegalovirus promoter and its effects in HeLa cells. Plasmid 62 (2), 119–127
  37. Красильщикова МС, Леонов ВП, Зацепина ОВ, Дейгин ВИ (2009). Исследование иммуносупрессорных свойств Тимодепрессина в экспериментальной модели аутоиммунных заболеваний.  (0),
  38. Zatsepina OV, Zharskaya OO, Prusov AN (2008). Isolation of the constitutive heterochromatin from mouse liver nuclei. Methods Mol Biol 463 (0), 169–180
  39. Shramovu EI, Khodarovich YM, Larionov OA, Zatsepina OV (2008). The status of nucleolus organizing regions in hybrids of pluripotent and somatic mouse cells cultured under different conditions. Tsitologiia 50 (4), 303–308
  40. Красильщикова МС, Дейгин ВИ, Зацепина ОВ (2008). Способностть циклоспорина А предотвращать образование аутоантител к фибрилларину у мышей. 3 (0), 166–170
  41. Filyasova EI, Zatsepina OV, Khodarovich YM, Larionov OA (2008). Growth and differentiation of cell hybrids obtained by fusing mouse PCC4aza1 teratocarcinoma cells and mouse spleen cells under different in vitro culture conditions. RUSS J DEV BIOL 39 (3), 151–157
  42. Zharskaya OO, Barsukova AS, Zatsepina OV (2008). Effect of roscovitine, a selective cyclin B-dependent kinase 1 inhibitor, on assembly of the nucleolus in mitosis. Biochemistry (Mosc) 73 (4), 411–419
  43. Grigoryev AA, Bulycheva TI, Sheval EV, Kalinina IA, Zatsepina OV (2008). Cytological indicators of overall suppression of protein synthesis revealed by staining with a new monoclonal antibody. Cell tissue biol 2 (2), 191–199
  44. Grigoryev AA, Zharskaya OO, Bulycheva TI, Zatsepina OV (2007). Changes in the status of nucleolus during long-term culturing of human HeLa cells. Bull Exp Biol Med 144 (3), 345–348
  45. Polzikov M, Magoulas C, Zatsepina O (2007). The nucleolar protein SURF-6 is essential for viability in mouse NIH/3T3 cells. Mol Biol Rep 34 (3), 155–160
  46. Zharskaya OO, Zatsepina OV (2007). Dynamics and mechanisms of the nucleolus reorganization during mitosis. Tsitologiia 49 (5), 355–359
  47. Zharskaya OO, Zatsepina OV (2007). The dynamics and mechanisms of nucleolar reorganization during mitosis. Cell tissue biol 1 (4), 277–292
  48. Красильщикова МС, Зацепина ОВ (2007). Тяжелые металлы как индукторы аутоиммунных процессов у человека и лабораторных животных. 3 (0), 54–63
  49. Romanova LG, Anger M, Zatsepina OV, Schultz RM (2006). Implication of nucleolar protein SURF6 in ribosome biogenesis and preimplantation mouse development. Biol Reprod 75 (5), 690–696
  50. Krasilshchikova MS, Ablaeva YV, Speransky AI, Zatsepina OV (2006). Induction of an autoimmunity-like process using regular mercury chloride administration to SJL mice. Dokl Biol Sci 409 (1), 296–298
  51. Красильщикова МС, Аблаева ЮВ, Сперанский АИ, Зацепина ОВ (2006). Индукция аутоиммунноподобного процесса с помощью регулярных инъекций хлорида ртути мышам линии SJL. 409 (1), 129–132
  52. Romanova L, Korobova F, Noniashvilli E, Dyban A, Zatsepina O (2006). High resolution mapping of ribosomal DNA in early mouse embryos by fluorescence in situ hybridization. Biol Reprod 74 (5), 807–815
  53. Sautkina EN, Tabdanov ED, Potapenko NA, Ovchinnikova TY, Zatsepina OV, Vladimirova NM (2005). Alterations of monomeric and oligomeric forms of the nucleolar protein B23/nucleophosmin in Hela cells during apoptosis induced by tumor necrosis factor. BIOL MEMBRANY 22 (5), 380–389
  54. Kunafina ER, Chaplina MV, Filyasova EI, Gibanova NV, Khodarovich YM, Larionov OA, Zatsepina OV (2005). Activation of nucleolar organizers during in vitro cultivation of mouse R1 embryonic stem cells. Ontogenez 36 (2), 102–109
  55. Gurchenkov VV, Polzikov MA, Magoulas C, Romanova LG, Zatsepina OV (2005). Properties and functions of a new nucleolar protein, Surf-6, in 3T3 mouse cells. Bioorg Khim 31 (6), 578–585
  56. Gurchenkov VV, Polzikov MA, Magoulas C, Romanova LG, Zatsepina OV (2005). Properties and functions of a new nucleolar protein, surf-6, in 3T3 mouse cells. Russ. J. Bioorganic Chem. 31 (6), 521–528
  57. Tychinsky VP, Kretushev AV, Klemyashov IV, Vyshenskaya TV, Shtil AA, Zatsepina OV (2005). Coherent phase microscopy, a novel approach to study the physiological state of the nucleolus. Dokl Biochem Biophys 405 (16), 432–436
  58. Kunafina ER, Chaplina MV, Filyasova EI, Gibanova NV, Khodarovich YM, Larionov OA, Zatsepina OV (2005). Activation of nucleolus organizing regions during in vitro cultivation of mouse R1 embryonic stem cells. RUSS J DEV BIOL 36 (2), 75–81
  59. Polzikov M, Zatsepina O, Magoulas C (2005). Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. Biochem Biophys Res Commun 327 (1), 143–149
  60. Levitskiy SA, Mukharyamova KS, Veiko VP, Zatsepina OV (2004). Identification of signal sequences determining the specific nucleolar localization of fibrillarin in HeLa cells. Mol Biol (Mosk) 38 (3), 483–492
  61. Vladimirova NM, Sautkina EN, Tabdanov ED, Bulycheva TI, Ovchinnikova TV, Zatsepina OV, Potapenko NA (2004). Revealing and characterization of monomeric and oligomeric forms of a nucleolar protein B23/nucleophosmin in Hela cells. BIOL MEMBRANY 21 (2), 94–101
  62. Levitskiy SA, Mukharyamova KS, Veiko VP, Zatsepina OV (2004). Identification of signal sequences determining the specific nucleolar localization of fibrillarin in HeLa cells. Mol Biol 38 (3), 405–413
  63. Prusov AN, Zatsepina OV (2002). Isolation of the chromocenter fraction from mouse liver nuclei. Biochemistry (Mosc) 67 (4), 423–431
  64. Dmitriev PV, Prusov AN, Petrov AV, Dontsova OA, Zatsepina OV, Bogdanov AA (2002). Mouse chromocenters contain associated telomeric DNA and telomerase activity. Dokl Biol Sci 383 (0), 171–174
  65. Jarskaja OO, Medzhidova AA, Fedorova NE, Kusch AA, Zatsepina OV (2002). Immunocytochemical reorganization of the nucleolus in human embryo fibroblasts infected with cytomegalovirus in vitro. Dokl Biol Sci 387 (0), 589–592