- science news Mechanism of coelenterazine chromophore photoinactivation from Beroe abissycola photoprotein is proposed
Scientists from IBCh RAS with colleagues from Photobiology Lab (IBP SB RAS) elucidated the structures of Beroe abissycola photoprotein’s chromophore photoinactivation products and proposed a mechanism of the photoinactivation process. The similarity of chemical transformations of photoprotein and GFP-like fluorescent protein chromophores was demonstrated for the first time. The results are published in Organic Letters. The project was funded by the RScF grant № 17-14-01169p.
- science news Essential role of zinc ions in TLR1 receptor activation
Toll-like receptors are the key players of the innate immune response. Despite the numerous studies and huge amount of data regarding these proteins, the structural basis of their functioning has not yet been clearly elucidated. Scientists from IBCh RAS, together with their colleagues from Moscow Institute of Physics and Technology and Changchun Institute of Applied Chemistry (China) discovered the essential role of zinc in the functioning of Toll-like receptor 1 and proposed possible mechanisms of zinc-mediated receptor activation. The work was funded by the RFBR grant 20-34-70024 and published in Communications Biology.
- science news New structural data allowed to study the mechanism of thermal activation of thermosensitive ion channels of the TRP family
Scientists from the Laboratory of biomolecular modeling of the IBCh RAS, together with colleagues from Columbia University (New York, USA), the University of Illinois (Peoria, USA), and the Institute of Physiology of the Czech Academy of Sciences (Prague, Czech Republic), have revealed the structural mechanism of heat-induced opening of temperature-sensitive TRP channels.
- science news Investigation of long-term fate of magnetic nanoparticles in mice
Scientists from Laboratory of molecular immunology of IBCh RAS performed first broad comprehensive study of factors which influence degradation rate of magnetic particles in mammals. For this aim magnetic spectral approach was developed, allowing non-invasive and quantitative measurement of magnetic particles in mice without influence of biogenic iron. Researchers studied the key factors that determine the degradation rate of nanoparticles: particle dose, size, zeta potential, type of polymer coating and internal architecture of nanoagents. The revealed deeper insights into the particle degradation in vivo may facilitate rational design of theranostic nanoparticles with predictable long-term fate in vivo. The work was published in ACS Nano.
- conferences Conference "Pathological changes in the central nervous system. From model to the patient."
- funds FEBS Excellence Awards
Please note that applications for the new FEBS Excellence Awards are now open (from 1st June) and will close on 1st September. The online application system is here: https://fellowships.febs.org/ea_2021 and full details can be found on the FEBS website here: https://www.febs.org/our-activities/fellowships/febs-excellence-awards/. FEBS Excellence Awards are intended to support research projects in the molecular life sciences from early-career group leaders. They are granted over three years and amount to €100,000.
- science news Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
International research team together with researchers from IBCh RAS studied molecular mechanisms of histone acetyltransferase KAT8 activity. The enzyme regulates DNA compactization and gene transcription regulation by acetylation of histone H4 and is essential for cell viability. The results are published in the journal Molecular Cell.
- science news 2021 research grants
In 2021, we are offering a series of research grants to stimulate innovative research in challenging areas of future importance. Grants of 40,000 € - 450,000 € per year for up to 3 years are available in the areas as further specified below. More info - researchgrants.merckgroup.com.
- science news Conformational changes in the receptor tyrosine kinase IRR during activation were determined
Researchers of the Laboratory of Receptor Cell Biology IBCh RAS together with colleagues from the IPCE RAS and IC RAS carried out a study of the IRR structure by atomic force microscopy and small-angle X-ray scattering. The conformations of the receptor in the active and inactive states have been determined; on the basis of the obtained data, an activation mechanism has been proposed.
- science news The role of natural mutations of the human protein SLURP-1 in the pathogenesis of Mal de Meleda skin disease has been determined
Mal de Meleda (MDM) is recessively inherited palmoplantar keratoderma associated with mutations in a gene encoding SLURP-1 protein. SLURP-1 is a paracrine regulator of keratinocyte homeostasis interacting with the α7 type nicotinic acetylcholine receptor (α7-nAChR). This receptor participates in control of growth, terminal differentiation, apoptosis and cornification of keratinocytes. Dysregulation of the α7-nAChR function due to SLURP-1 deficiency or point mutations of this protein may underlie MDM pathogenesis.
- science news Genomic DNA i-motifs as fast sensors responsive to near-physiological pH microchanges
Researchers from Federal Research and Clinical Center of Physical-Chemical medicine and Institute of Bioorganic Chemistry RAS, in collaboration with Skolkovo University of Science and Technology and D.Mendeleev University of Chemical Technology of Russia developed simple and robust sensors for detecting microchanges in intracellular pH.
- science news From cytoskeleton to pluripotency: a new mechanism for regulating stem status of the embryonic cells
November 17, 2020
Researchers from the Laboratory of Molecular Bases of Embryogenesis (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS), in technical cooperation with colleagues from the Department of Metabolism and Redox Biology (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS), the Laboratory of Genomics and Epigenomics of Vertebrates in the Federal Center "Fundamentals of Biotechnology" RAS, as well as with colleagues from the Cell Motility Group of the Institute of Protein Research RAS, discovered a previously unknown mechanism of the regulation of the activity of genes that determine the pluripotent status of the embryonic stem cells.
- science news Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape
November 17, 2020
Researchers of the Laboratory of Molecular Immunology, IBCh RAS, in collaboration with Russian colleagues have shown that the strategy of targeting of anticancer toxins to two different surface antigens on the surface of a cancer cell is effective in the treatment of not only primary solid tumors, but also distant metastases.
- science news Liquid drop of DNA libraries reveals total genome information
October 22, 2020
Unlike the tightly controlled replication of DNA in living cells, PCR amplification, a “workhorse” of molecular biology, balances between simplicity and accuracy. Conventional “bulk” PCR often yields inefficient and nonuniform amplification of complex templates in DNA libraries, introducing unwanted biases.
- science news Discovery of the novel protein encoded in mammalian mitochondrial DNA polymerase gene POLG
September 25, 2020
Researchers from Laboratory of bioinformatics approaches in combinatorial chemistry and biology and Laboratory of high-performance screening of biological objects together with colleagues from Moscow State University and University College Cork (Ireland) discovered novel protein POLGARF, which is encoded in alternative reading frame of mitochondrial DNA polymerase POLG mRNA. The results of this study are published in PNAS.