Structural basis of functioning of the neurotrophin receptors

April 20, 2022 — December 31, 2024

Goncharuk S.A. (PI), Artem'eva L.E. (Co-PI), Kot E.F. (Co-PI), Lushpa V.A. (Co-PI), Savitskaya A.G. (Co-PI), Bedanokova D.R., Shabalkina A.V.

Laboratory of biomolecular NMR-spectroscopy

Grant, RSF

List of publications

  1. Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, Kuutti M, Fred SM, Elsilä LV, Sakson S, Cannarozzo C, Diniz CRAF, Seiffert N, Rubiolo A, Haapaniemi H, Meshi E, Nagaeva E, Öhman T, Róg T, Kankuri E, Vilar M, Varjosalo M, Korpi ER, Permi P, Mineev KS, Saarma M, Vattulainen I, Casarotto PC, Castrén E (2023). Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci 26 (6), 1032–1041
  2. Baleeva NS, Bogdanova YA, Goncharuk MV, Sokolov AI, Myasnyanko IN, Kublitski VS, Smirnov AY, Gilvanov AR, Goncharuk SA, Mineev KS, Baranov MS (2024). A Combination of Library Screening and Rational Mutagenesis Expands the Available Color Palette of the Smallest Fluorogen-Activating Protein Tag nanoFAST. Int J Mol Sci 25 (5),
  3. Diniz CRAF, Crestani AP, Casarotto PC, Biojone C, Cannarozzo C, Winkel F, Prozorov MA, Kot EF, Goncharuk SA, Marques DB, Zacharias LR, Autio H, Sahu MP, Borges-Assis AB, Leite JP, Mineev KS, Castrén E, Resstel LBM (2024). Fluoxetine and Ketamine Enhance Extinction Memory and Brain Plasticity by Triggering the p75 Neurotrophin Receptor Proteolytic Pathway. Biol Psychiatry 97 (3), 248–260
  4. Kot EF, Goncharuk SA, Franco ML, McKenzie DM, Arseniev AS, Benito-Martínez A, Costa M, Cattaneo A, Hristova K, Vilar M, Mineev KS (2024). Structural basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB. Nat Commun 15 (1), 9316
  5. Bedanokova DR, Goncharuk MV, Shabalkina AV, Lushpa VA, Arseniev AS, Bocharov EV, Mineev KS, Goncharuk SA (2024). Production and Refolding of the Ligand-Binding Domain of TrkA Receptor with the Extracellular Juxtamembrane Region. Russ. J. Bioorganic Chem. 50 (6), 2589–2595