-Структурно-функциональные исследования ионного канала TRPA1: от лиганд-рецепторных взаимодействий к новым анальгетикам

January 6, 2022 — December 31, 2024

Shenkarev Z.O. (PI)

Laboratory of structural biology of ion channels

Grant, RSF

List of publications

  1. Lyukmanova EN, Mironov PA, Kulbatskii DS, Shulepko MA, Paramonov AS, Chernaya EM, Logashina YA, Andreev YA, Kirpichnikov MP, Shenkarev ZO (2023). Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer. Toxins (Basel) 15 (6), 378
  2. Mironov PA, Shenkarev ZO (2023). Disulfide bond patterns in the toxins of spiders of the Ctenidae family. Comparison with AlphaFold 2.0 predictions. ВМУ.Биология 78 (3S), 13–20
  3. Mironov PA, Shenkarev ZO (2023). Patterns of a Disulfide Bond Formation in Toxins of Spiders from the Ctenidae Family: A Comparison with Predictions of the AlphaFold 2.0 Neural Network. Moscow Univ Biol Sci Bull 78 (Suppl 1), S9–S16
  4. (conference) Lyukmanova EN, Kulbatskii DS, Mironov PA, Oreshkov SD, Paramonov AS, Menshov AS, Kvetkina AN, Klimovich AA, Pislyagin EA, Leichenko EV, Shenkarev ZO (2024). Spatial structure, analgesic effects, and TRPA1 modulation of the Kunitz-type sea-anemone peptide HCIQ2C1. Toxicon 248,
  5. Kvetkina AN, Oreshkov SD, Mironov PA, Zaigraev MM, Klimovich AA, Deriavko YV, Menshov AS, Kulbatskii DS, Logashina YA, Andreev YA, Chugunov AO, Kirpichnikov MP, Lyukmanova EN, Leychenko EV, Shenkarev ZO (2024). Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo. Mar Drugs 22 (12), 542
  6. Lyukmanova EN, Shenkarev ZO (2024). Toxins from Animal Venom—A Rich Source of Active Compounds with High Pharmacological Potential. Toxins (Basel) 16 (12), 512
  7. Kvetkina AN, Klimovich AA, Deriavko YV, Pislyagin EA, Menchinskaya ES, Bystritskaya EP, Isaeva MP, Lyukmanova EN, Shenkarev ZO, Aminin DL, Leychenko EV (2025). Sea Anemone Kunitz Peptide HCIQ2c1 Reduces Histamine-, Lipopolysaccharide-, and Carrageenan-Induced Inflammation via the Suppression of Pro-Inflammatory Mediators. Int J Mol Sci 26 (1), 431
  8. Shulepko MA, Zhang M, Zhivov EA, Kulbatskii DS, Paramonov AS, Che Y, Kuznetsov AV, Popov AV, Kirpichnikov MP, Shenkarev ZO, Lyukmanova EN (2025). Recombinant Production, Species-Specific Activity at the TRPA1 Channel, and Significance of the N-Terminal Residue of ProTx-I Toxin from Thrixopelma PruriensTarantula Venom. Acta Naturae 17 (4), 121–129