Institute of
bioorganic chemistry

Liposomes are an established drug delivery platform that has paved the way to clinic for nanomedicine drugs. In the body, interactions of liposomes, as well as other drug delivery vehicles, are mediated by the complex dynamic layer of plasma proteins adsorbed on the surface, the protein corona. The review summarizes the data on liposome protein corona, tracing the path from interactions of individual proteins to the effects mediated by the corona in vivo. It critically assesses protein corona isolation and analysis techniques and offers a classification of the approaches to exploitation of the protein corona—rather than elimination thereof—based on the bilayer composition–protein corona composition–molecular interactions–biological performance relationship.