Introduction. Glycans play an important role in the pathogenesis of malignant neoplasms, including stomach can-cer. In recent years, the attention of many researchers has been drawn to mannose (Man) – hexose, which is anindispensable component of all N-chains of glycoproteins involved in both normal physiological and pathologicalprocesses.Aim. To investigate the role of innate immunity factors and ways to influence them through mannose and man-nose-containing glycans in gastric cancer patients