J. Nanotheranostics, 2025, 6(1):2

PTT-Mediated Inhibition of Cancer Proliferation and Tumor Progression by DARPin-Coated Gold Nanoparticles

Targeting HER2-positive cancer cells with precision therapies is a critical challenge in oncology. Here, we present a study on gold nanoparticles (AuNPs) conjugated with DARPin_9-29, a designed ankyrin repeat protein with high specificity and affinity for HER2 receptors. In this study, we investigate the therapeutic potential of AuNP-DARPin_9-29 conjugates, which was synthesized and characterized by us earlier, for photothermal therapy (PTT). By combining AuNP-DARPin treatment with visible light illumination, we show selective inhibition of HER2-positive cancer cell proliferation and tumor progression in a murine model. The results highlight the effectiveness of AuNP-DARPin in disrupting cancer cell viability and reducing tumor growth, providing a cost-effective and targeted approach for combating HER2-positive cancers.

Proshkina GM, Shramova EI, Serova EV, Myachev EA, Mirkasymov AB, Deyev SM, Kotlyar AB

Laboratory of molecular immunology

: 10.3390/jnt6010002
Scopus: 2-s2.0-105046491309
IBCH: 12702
Ссылка на статью в журнале: https://www.mdpi.com/2624-845X/6/1/2
Кол-во цитирований на 08.2026: 2
Данные статьи проверены модераторами 2026-10-11

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