075-15-2024-536

Oncotheranostics and problems of resistance to antitumor and antibacterial drugs

April 23, 2024 — December 31, 2026

Deyev S.M. (PI), Alekseeva N.A., Alekseeva L.G., Aliper E.T., Alferova V.A., Andrianova A.G., Babkova Y.S., Baranova A.A., Baranova M.N., Belogurov A.A., Bogachuk A.P., Bocharov E.V., Burenina O.Y., Bychkov M.L., Veretenenko I.I., Volkov D.V., Gabibov A.G., Gordeeva V.D., Gorelik L.V., Gryaznova O.Y., Gulyak E.L., Deryabin A.S., Dobrochaeva K.L., Evpak A.S., Egorova N.S., Emel'yanov E.A., Ermolaeva E.O., Efremov R.G., Zhitlov M.Y., Zhuchkov V.A., Zakharova M.Y., Zvyagin A.V., Zelepukin I.V., Zinchenko A.A., Kalganova A.I., Kirichenko A.V., Kirpichnikov M.P., Knorre V.D., Kovaleva D.K., Kovalenko E.I., Kokaeva I.S., Konovalova E.V., Konshina A.G., Korotkova N.A., Korshun V.A., Kotel'nikova O.V., Kotelnikova P.A., Kravchenko T.V., Krylov N.A., Kudriaeva A.A., Kuzmina O., Kurbatskaya I.N., Lazarev I.V., Logvinov A.S., Lyukmanova E.N., Mazur R.V., Mallaev R.A., Mirzoeva N.Z., Mirkasymov A.B., Musatova O.E., Nechaeva A.M., Nikitin T.D., Nikonova A.V., Nolde D.E., Odzhomoko L.O., Orlova D.A., Panina I.S., Pakhomov A.A., Pahomova T.E., Pizhonkov N.A., Pipiya S.O., Polyansky A.A., Pohorukov D.A., Prokopenko Y.A., Proshkina G.M., Rodionov V.I., Rotanova T.V., Rubcov Y.P., Ryabukha Y.A., Savateeva N.S., Sapozhnikova K.A., Serova E.V., Sinichich A.A., Smirnov I.V., Sogomonyan A.S., Spallone A., Stepanova (Ukrainskaya) V.M., Streltsova M.A., Sutugin Y.A., Terekhov S.S., Frolova A.Y., Khavroshechkina E.V., Khodarovich Y.M., Kholodenko R.V., Tsetlin V.I., Chumakov S.P., Shilova P.A., Shlepova O.V., Shramova E.I., Shul'ga A.A.

Laboratory of biocatalysis, Laboratory of hormonal regulation proteins, Laboratory of proteolytic enzyme chemistry, Laboratory of antibiotic resistance, Laboratory of cell interactions, Laboratory of molecular immunology, Laboratory of molecular theranostics, Laboratory of biomolecular NMR-spectroscopy, Laboratory of biomolecular modeling, Group of in silico analysis of membrane proteins structure, Laboratory of Neuroimmune Processes, Laboratory of bioengineering of neuromodulators and neuroreceptors, Laboratory of molecular oncology, Laboratory of molecular design and synthesis, Laboratory of molecular virology, Laboratory of Instruments for Diagnosis and Therapy of Infectious Diseases

Grant, Budget

List of publications

  1. Belyaev IB, Griaznova OY, Yaremenko AV, Deyev SM, Zelepukin IV (2025). Beyond the EPR effect: Intravital microscopy analysis of nanoparticle drug delivery to tumors. Adv Drug Deliv Rev 219, 115550
  2. Lohan S, Konshina AG, Tiwari RK, Efremov RG, Maslennikov I, Parang K (2024). Broad-Spectrum Activity of Membranolytic Cationic Macrocyclic Peptides Against Multi-Drug Resistant Bacteria and Fungi. Eur J Pharm Sci 197, 106776
  3. Yaremenko AV, Melikov RO, Pechnikova NA, Belyaev IB, Ringaci , Yaremenko TV, Mirkasymov AB, Tamgin AA, Rodionov VI, Dolotova SM, Plisko GA, Semivelichenko ED, Rogova AS, Muslimov AR, Ivkina AS, Ivkin DY, Erichev VP, Deyev SM, Avetisov SE, Li Y, Liu H, Zelepukin IV (2024). Modification of contact lenses via metal-organic frameworks for glaucoma treatment. Aggregate ,
  4. Krivitskaya AV, Kuryshkina MS, Eremina MY, Smirnov IV, Khrenova MG (2024). Molecular Basis of Influence of A501X Mutations in Penicillin-Binding Protein 2 of Neisseria gonorrhoeae Strain 35/02 on Ceftriaxone Resistance. Int J Mol Sci 25 (15), 8260
  5. Bragina OD, Tashireva LA, Loos DM, Vtorushin SV, Shulga AA, Konovalova EN, Borodina ME, Chernov VI, Tolmachev VM, Deyev SM (2024). Evaluation of HER2/neu Expression in Metastatic Axillary Lymph Node Tissue of Breast Cancer Patients Using [99mTc]Tc-(HE)3-G3. Acta Naturae 16 (2), 22–29
  6. Zelchan R, Chernov V, Medvedeva A, Rybina A, Bragina O, Mishina E, Larkina M, Varvashenya R, Fominykh A, Schulga A, Konovalova E, Vorobyeva A, Orlova A, Tashireva L, Deyev SM, Tolmachev V (2024). Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [99mTc]Tc(CO)3-(HE)3-Ec1 for Visualization of EpCAM-Expressing Lung Cancer. Cancers (Basel) 16 (16), 2815
  7. Proshkina GM, Shramova EI, Mirkasyimov AB, Griaznova OY, Konovalova EV, Schulga AA, Deyev SM (2024). The Barnase-Barstar-based pre-targeting strategy for enhanced antitumor therapy in vivo. Biochimie ,
  8. Belyaev IB, Mirkasymov AB, Rodionov VI, Babkova JS, Nikitin PI, Deyev SM, Zelepukin IV (2024). MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner. Biomed Mater 19 (6),
  9. Alekseeva NA, Boyko AA, Shevchenko MA, Grechikhina MV, Streltsova MA, Alekseeva LG, Sapozhnikov AM, Deyev SM, Kovalenko EI (2024). Three-Dimensional Model Analysis Revealed Differential Cytotoxic Effects of the NK-92 Cell Line and Primary NK Cells on Breast and Ovarian Carcinoma Cell Lines Mediated by Variations in Receptor–Ligand Interactions and Soluble Factor Profiles. Biomedicines 12 (10), 2398
  10. Konshina AG, Bocharov EV, Konovalova EV, Schulga AA, Tolmachev V, Deyev SM, Efremov RG (2024). Structural Basis of Activity of HER2-Targeting Construct Composed of DARPin G3 and Albumin-Binding Domains. Int J Mol Sci 25 (21), 11370
  11. Burenina OY, Lazarevich NL, Kustova IF, Shavochkina DA, Moroz EA, Kudashkin NE, Patyutko YI, Rubtsova MP, Dontsova OA (2025). Upregulation of long noncoding RNAs LINC00941 and ABHD11-AS1 is associated with intrahepatic cholangiocarcinoma. Sci Prog 108 (1), 368504251330019