Russ. J. Bioorganic Chem., 2023, 49(4):905-911

Synthesis of Liposomes Conjugated with CpG-Oligonucleotide and Loaded with a Set of T-Cell Epitopes of the SARS-CoV-2 Virus

The synthesis of a lipid conjugate of immunostimulatory oligodeoxyribonucleotide CpG-ODN (PD-CpG-DOPE) is described. Liposomes loaded with a composition of T-cell epitopes of the SARS-CoV-2 virus (7 peptides) and carrying the PD-CpG-DOPE conjugate in the membrane, including lyophilized liposomes suitable for long-term storage, were prepared. In vitro experiments on mouse peritoneal exudate cells showed a tendency to increase the immunogenicity of liposomes with peptides when the PD-CpG-DOPE conjugate was introduced into the lipid bilayer, compared with the addition of the (commercial) phosphorothioate derivative of CpG-ODN in solution.

Tretiakova DS, Azhikina TL, Boldyrev IA, Svirshchevskaya EV, Vodovozova EL

Laboratory of cell interactions, Laboratory of regulatory transcriptomics, Laboratory of lipid chemistry

: 10.1134/S1068162023040210
Scopus: 2-s2.0-85168505803
IBCH: 10849
Ссылка на статью в журнале: https://link.springer.com/10.1134/S1068162023040210
Кол-во цитирований на 03.2024: 0
Данные статьи проверены модераторами 2023-08-28

Список научных проектов, где отмечена публикация

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