RUSS CHEM REV, 2015, 84(1):1-26

Man-made antibodies and immunoconjugates with desired properties: Function optimization using structural engineering

The modular structure of natural antibodies and approaches to its targeted modifications and combination with other structural elements and effector molecules are considered. The review covers modern methods for immunoglobulin engineering and promising strategies for the creation and applications of monoclonal antibodies, their derivatives and analogues, including abzymes and scaffolds, oriented to the use in the diagnosis and targeted therapy of cancer and other socially significant diseases. The bibliography includes 225 references.

IBCH: 4232
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Список научных проектов, где отмечена публикация

  1. -Комплексный подход к биоинженерии мультифункциональных соединений направленного действия для диагностики и терапии рака (January 6, 2014 — December 31, 2018). Deyev S.M.. Grant, RSF.