The unit was disbanded in 2023. It is part of the unit Laboratory of optical bioimaging.
Group of molecular tags for optical nanoscopy
The Group is working on the creation of reporter systems adapted for live-cell nanoscopy. The group was formed in 2018.
- Protein-PAINT method: the reversible interaction of a genetically encoded reporter protein and a small-molecule fluorogenic dye freely penetrating the cytoplasmic membrane allows for high photostability and labeling density of target structures. We have developed green, orange, and red fluorogen-protein pairs suitable for localization microscopy (SMLM) as well as STED
- Protein-PAINT / IRES method: a fully genetically encoded version of protein-PAINT based on the reversible interaction of short peptides (K/E helices). The novel protein labeling system allows for high-density labeling of target structures in prolonged live-cell nanoscopy experiments.
- The use of spontaneous blinking of fluorescent proteins and dyes for nanoscopy
- Genetically encoded tags for STED and RESOLFT
- luminescence microscopy and imaging
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