Genetically encoded fluorescent pH probe for precise monitoring of cellular biochemistry
One of the directions of the Molecular Technologies Laboratory is the development of new tools for bioimaging and optogenetics. Yulia Ermakova, Vsevolod Belousov and other lab members, in an article in Chemical Communications, describe a new member of SypHer family of genetically encoded pH indicators, SypHer3s.
- Kurt Wüthrich took part in the workshop of the Structural biology department
Professor Kurt Wüthrich, Nobel Laureate in Chemistry, 2002, visited Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS and took part in the workshop of the Structural biology department of the Institute (headed by Prof. Alexander Arseniev).
- Ras-dva: make regeneration great again
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- A bright bantam: BrUSLEE – green fluorescent protein with the unique properties
Researchers from the Biophotonics lab of IBCH RAS (Anastasia Mamontova, Konstantin Lukyanov and Alexey Bogdanov) designed a new green fluorescent protein that combines high fluorescence brightness and short fluorescence lifetime. They used a semi-rational protein evolution approach. Their collaborators from Bach Institute of Biochemistry and Semenov Institute of Physical Chemistry helped with the time-resolved fluorescence analysis (FLIM) that allowed characterizing the physical properties of this perspective probe. Research has recently been published in the Scientific Reports.
- Marcus Conrad lecture "Ferroptosis: mechanisms and pharmacological amenability"
X.15 (This event is over)
Monday, October 15th, 15:00, Small Hall, Marcus Conrad (Institute of Developmental Genetics, Helmholtz Zentrum München) will give a talk "Ferroptosis: mechanisms and pharmacological amenability".
- International conference "Biomembranes - 2018" at MIPT
X.1–5 (This event is over)
Dear Colleagues! We are very pleased to invite you to participate in the International Conference “BIOMEMBRANES 2018”, which will be held on October 1-5, 2018 at the Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Moscow region, Russia.
- Michael Gütschow lecture "Design and Synthesis of Novel Peptidomimetics as Inhibitors of Human Proteases"
IX.7 (This event is over)
On Friday, September 7 at 14:00 in the Small Hall, the General Seminar of the IBCh RAS will be held. The lecture will be delivered by prof. Michael Gutchev from Bonn University, Germany.