Adaptive immune response of identical twins to live vaccine
T-cell receptors (TCRs) play a key role in adaptive immunity. TCR repertoire is very diverse and unique to each individual because it forms in the stochastic DNA recombination process. The group of scientists from the Department of genomics of adaptive immunity in collaboration with ENS (Paris, France) studied TCR repertoires of identical twins after immunization with a live vaccine. In each donor, they identified about a thousand different T-cell clones responding to immunization. Responding clones have almost unique repertoire in each donor with higher overlap in identical twin pairs. The study was supported by RSF and published in Proceedings of the National Academy of Sciences.
- Scientists present a fully genetically encodable bioluminescent system
Scientists from Russia, UK, Spain, Brazil, Japan, and Austria discovered the essential set of enzymes that allows glowing fungi to emit light. The bioluminescent system includes a brand- new luciferase and three enzymes that enable biosynthesis of fungal luciferin from a widespread metabolite – caffeic acid – as well as its recycling. The genes encoding this “caffeic acid cycle” make up a unique molecular toolkit that allows to turn any higher organism into a glowing one. The work was published in Proceedings of the National Academy of Sciences of the United States of America.
- Kurt Wüthrich took part in the workshop of the Structural biology department
Professor Kurt Wüthrich, Nobel Laureate in Chemistry, 2002, visited Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS and took part in the workshop of the Structural biology department of the Institute (headed by Prof. Alexander Arseniev).
- Ras-dva: make regeneration great again
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- Microscopic Imaging of Epigenetic Landscape - A Universal Platform to Study Epigenetic Changes at Single Cell Level
II.15 (This event is over)
- "Molecular Brain" seminar
I.22 (This event is over)
The seminar will take place on January 22 at 16:00 in the Minor hall. Professor Leonard Khiroug from the University of Helsinki (Finland) will talk about the "awake microscopy" methodology utilized for high-resolution brain imaging. Everyone is cordially invited.
- Lecture by Prof. Zhang Shuguang «The QTY Code: A tool for designing detergent-free membrane proteins»
XII.24.18 (This event is over)
Prof. Zhang Shuguang from MIT will deliver a lecture entitled «The QTY Code: A tool for designing detergent-free membrane proteins». Date and time: Mon 24 December 2018 15:00. Location: Conference hall at 3rd floor BON IBCh.