The example of a wide interactome that proteins can have. Source: Nature

Researchers from IBCh together with colleagues from the United States found that mammalian BetaM protein has a different structure than their relatives. Functional experiments shown that the mammalian "native" BetaM protein function has been lost, but the new one has appeared. In fish, amphibians and birds BetaM still performs the original function of neural transmission, but mammals instead it regulates gene expression in muscle.


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    A team of biologists from Russia, Czech Republic, Israel, USA, and Spain systematically measured how mutations interact within a protein coding gene. They studied tens of thousands of mutants of the green fluorescent protein from the jellyfish Aequorea victoria. The results, published in Nature, uncover mechanisms of protein evolution and deepen our understanding of why effects of mutations are dependent on the genetic context in which they occur. 

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    Imagine that you have found a second job with a few numbers of duties. At the new place, you have to establish relations with the team, but instead to restrict contact with just two colleagues, you become the soul of a large company. BetaM protein also expanded the range of its functions: from participation in the transmission of nerve impulses throughout the body of most animals to the regulation of gene expression in the muscles in mammals exclusively. This BetaM protein began to interact with a large number of partners than ever before that radically changes our understanding of the evolution of the "behavior" of proteins. It was published by scientists from Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences in cooperation with the staff of the University of Toledo (USA) in Scientific Reports.

  • Postgraduate students from IBCh will receive a SkolTech scholarship to study regeneration and T-cell immunity science news V.10

    Scientific projects of postgraduate students of the Institute of Bioorganic Chemistry of Russian Academy of Sciences have become the winners of the program of Skolkovo Institute of Science and Technology to support young scientists in systems biology. The researchers will receive scholarship money to study two issues: responses of T-cell immunity to a live vaccine against yellow fever in genetically identical twins, as well as search and analysis of genetic target gene, which is responsible for brain development and regeneration of the body appendages in vertebrates.