Transgenic aspen plants (Populus tremula) with the expression of recombinant xyloglucanase sp-Xeg show an increased growth rate, altered composition and properties of wood, and the phenotype of the plant as a whole
Wood formation is an extremely complex process, controlled by more than 40,000 genes.At the cellular level, wood is nothing but lignified cell walls that constructed from three main structural biopolymers - cellulose, hemicellulose and lignins. The main component of hemicellulose is xyloglucans, which form short cross-links between long cellulose filaments. The more stitches, the lower the elasticity of the cell wall. Scientists from the Group of Forest Biotechnology together with russian and foreign colleages suggested that partial, rather than excessive, hydrolysis of xyloglucans may affect the elasticity of the cell wall, and indirectly the growth rate of the tree. In transgenic models of aspen, they have shown that superexpression of recombinant xyloglucanase from the fungus P.canescens leads not only to hydrolysis of cell wall xyloglucans, but also is accompanied by a complex of changes in the phenotype: the content of cellulose in wood is increased, the carbohydrate composition of wood are changed, as a result, the wood began to decompose more slowly. The work is published in BMC Plant Biology. Learn more
- A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding
Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. A new subfamily of AmiN-like kinases, isolated from the Siberian bear microbiome, inactivates antibiotic amicoumacin by phosphorylation. The nanomolar substrate affinity defines AmiN as a phosphotransferase with a unique catalytic efficiency proximal to the diffusion limit. Crystallographic analysis and multiscale simulations revealed a catalytically perfect mechanism providing phosphorylation exclusively in the case of a closed active site that counteracts substrate promiscuity. AmiN kinase is a member of the previously unknown subfamily representing the first evidence of a specialized phosphotransferase bioscavenger.
- Transgenic aspen plants (Populus tremula) with the expression of recombinant xyloglucanase sp-Xeg show an increased growth rate, altered composition and properties of wood, and the phenotype of the plant as a whole
Scientists from the Group of Forest Biotechnology IBCh RAS obtained the transgenic aspen with acceletated growth, a modified carbohydrate composition and a slower rate of decomposition of wood.
- Structure of Supramers Formed by the Amphiphile Biotin‐CMG‐DOPE
Scientists from the Department of Chemical Biology of Glycans and Lipids, the Department of structural biology and the Department of Biomaterials and Bionanotechnology IBCh RAS in collaboration with Russian and foreign colleges published a paper in ChemistryOpen on the study of conjugate of a biotin with DOPE (dioleoylphosphatidyl ethanolamine) and on its interaction with streptavidin.
- Lipids 2021 Conference
Lipids 2021 Conference, October 19-21, 2021, IBCH RAS, Moscow
- Lecture by Director-General of the ICGEB Lawrence Banks «Human Papillomaviruses: From Infectious Entry to Malignancy»
I.27 (This event is over)
ICGEB Director-General Group Leader Lawrence Banks will deliver a lecture entitled «Human Papillomaviruses: From Infectious Entry to Malignancy». Date and time: Mon 27 January 2020 14:00. Location: Small conference hall at 3rd floor BON IBCh.
- LIGHTS ON: Molecular Imaging of disease dynamics in vivo
IX.27 X.11.19 (This event is over)
Abhijit De PhD Scientific Officer ‘F’ and Principal Investigator Head, Molecular Functional Imaging Lab Advanced Centre of Training Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.