
Conformational changes in the receptor tyrosine kinase IRR during activation were determined
Researchers of the Laboratory of Receptor Cell Biology IBCh RAS together with colleagues from the IPCE RAS and IC RAS carried out a study of the IRR structure by atomic force microscopy and small-angle X-ray scattering. The conformations of the receptor in the active and inactive states have been determined; on the basis of the obtained data, an activation mechanism has been proposed. This work was supported by projects of the Russian Foundation for Basic Research 20-04-00959, 17-00-00486, the Ministry of Science and Higher Education of the Russian Federation and published in two articles in the Journal of Biological Chemistry [1] [2]. Learn more
News 
- Conformational changes in the receptor tyrosine kinase IRR during activation were determined
science news
IV.5 Researchers of the Laboratory of Receptor Cell Biology IBCh RAS together with colleagues from the IPCE RAS and IC RAS carried out a study of the IRR structure by atomic force microscopy and small-angle X-ray scattering. The conformations of the receptor in the active and inactive states have been determined; on the basis of the obtained data, an activation mechanism has been proposed.
- The role of natural mutations of the human protein SLURP-1 in the pathogenesis of Mal de Meleda skin disease has been determined
science news
III.29 Mal de Meleda (MDM) is recessively inherited palmoplantar keratoderma associated with mutations in a gene encoding SLURP-1 protein. SLURP-1 is a paracrine regulator of keratinocyte homeostasis interacting with the α7 type nicotinic acetylcholine receptor (α7-nAChR). This receptor participates in control of growth, terminal differentiation, apoptosis and cornification of keratinocytes. Dysregulation of the α7-nAChR function due to SLURP-1 deficiency or point mutations of this protein may underlie MDM pathogenesis.
- Genomic DNA i-motifs as fast sensors responsive to near-physiological pH microchanges
science news
I.4 Researchers from Federal Research and Clinical Center of Physical-Chemical medicine and Institute of Bioorganic Chemistry RAS, in collaboration with Skolkovo University of Science and Technology and D.Mendeleev University of Chemical Technology of Russia developed simple and robust sensors for detecting microchanges in intracellular pH.
Events 
- "Molecular Brain" seminar dedicated to Eugene Grishin’s 75th anniversary
science news
IV.27 The open seminar of the Department of Molecular Neurobiology will take place on April 27 at 11:00 in the Great Assembly Hall. The program includes presentations by colleagues, students, friends and associates of Eugene Grishin. We cordially invite everyone interested in modern work in the field of toxins, ion channels and neurobiology! Live broadcast in Zoom.
- International School "Molecular mechanisms of neurodegenerative diseases"
conferences
XI.26.20 (This event is over) Moscow Institute of Physics and Technology (MIPT) invites you to take part in the International school for young scientists "Molecular mechanisms of neurodegenerative diseases", which will be held on November 26, 2020 online.
- Lecture by Director-General of the ICGEB Lawrence Banks «Human Papillomaviruses: From Infectious Entry to Malignancy»
science news
I.27.20 (This event is over) ICGEB Director-General Group Leader Lawrence Banks will deliver a lecture entitled «Human Papillomaviruses: From Infectious Entry to Malignancy». Date and time: Mon 27 January 2020 14:00. Location: Small conference hall at 3rd floor BON IBCh.