Bioorg Khim, 2005, 31(4):399-403
The study of coupling agents for the phosphorylation of 3′-azido-3′-deoxythymidine with [32P]orthophosphoric acid
The kinetics of 3′-azido-3′-deoxythymidine phosphorylation with [32P]orthophosphoric acid was studied in the presence of various coupling agents. The most effective method with the use of BrCN provided the isolation of the target 3′-azido-3′-deoxythymidine 5′-[ 32P]monophosphate in 46% yield and a high specific radioactivity (100 Ci/mmol).
Scopus: 2-s2.0-33644636810
: 16119459
IBCH: 1110
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