- science news Ras-dva: make regeneration great again
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- science news A bright bantam: BrUSLEE – green fluorescent protein with the unique properties
Researchers from the Biophotonics lab of IBCH RAS (Anastasia Mamontova, Konstantin Lukyanov and Alexey Bogdanov) designed a new green fluorescent protein that combines high fluorescence brightness and short fluorescence lifetime. They used a semi-rational protein evolution approach. Their collaborators from Bach Institute of Biochemistry and Semenov Institute of Physical Chemistry helped with the time-resolved fluorescence analysis (FLIM) that allowed characterizing the physical properties of this perspective probe. Research has recently been published in the Scientific Reports.
- science news Antibiotic from the bear's mouth
Scientists from the Laboratory of biocatalysis developed a new microfluidics-based ultrahigh-throughput technology for the “deep functional profiling” of microbial communities and used it to search for bacteria producing new antibiotics in the microbiome of the Siberian bear's oral cavity. This methodology allowed them not only to find the antibiotic amicoumacin, elucidating the mechanisms of its biosynthesis and self-resistance, but also to investigate the spectrum of its activity at the level of various bacterial communities. The results published in PNAS will find numerous applications in the field of antibiotic discovery and will help to solve the problem of antibiotic resistance.
- science news Visit of Delegation of Ministry of Science, Technology and Space of Israel
- science news Spider venom may help to stop neuronal death
Venoms of spiders and wasps contain acylpolyamines that act as high-affinity blockers of ionotropic receptors for glutamate, the main excitatory neurotransmitter in the human central nervous system (CNS). The first representative of acylpolyamines, argiopin from the venom of the orb-weaver spider Argiope lobata, was discovered in 1986 by Eugene Grishin’s team at IBCh RAS. Here, an international team of scientists, including a researcher from IBCh RAS, has used cryo-electron microscopy (cryo-EM) to determine the first atomic structure of an argiopin-glutamate receptor complex. This structure will help to design new drugs for treatment of neurodegenerative diseases. The study is published in Neuron.
- science news Fast and safe: new reversibly switchable fluorescent proteins for live-cell nanoscopy
Russian scientists together with colleagues from Sweden and the USA developed red fluorescent tags that are safe for nanoscopy in living cells. This work was funded by a grant from the Russian Science Foundation (RSF), and the results are published in Nature Methods journal.
- science news Genetically encoded fluorescent pH probe for precise monitoring of cellular biochemistry
One of the directions of the Molecular Technologies Laboratory is the development of new tools for bioimaging and optogenetics. Yulia Ermakova, Vsevolod Belousov and other lab members, in an article in Chemical Communications, describe a new member of SypHer family of genetically encoded pH indicators, SypHer3s.
- science news Spider venom will cure from paralysis
Scientists from IBCh RAS together with foreign colleagues discovered that a toxin from the venom of the spider Heriaeus melloteei may serve as a hit in drug discovery for hypokalemic periodic paralysis type 2. The disease is caused by mutations in the gene encoding voltage-gated sodium channels NaV1.4, characteristic of skeletal muscles. As a result of the mutations, these channels conduct aberrant currents, the muscles are unable to respond to the signals of the nervous system, and weakness develops followed by paralysis. Until now, there is no reliable medication for all cases of this disease. The results of the work are published in the Proceedings of the National Academy of Sciences of the USA (PNAS).
- science news Lindoldhamine can activate the human ASIC3 channel
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH.
- science news Open call for research fellowships in Systems Biology
The Skoltech Center for Data Intensive Biomedicine and Biotechnology is proud to announce for the third time an open call for research fellowships in Systems Biology. Application period: 20 February 2018 to 15 March 2018 (Deadline: 23:59, Moscow time). The total amount of support is 630,000 rubles per year. Period: 3-year. Deadline: 15-03-2018 23:59 For more information on who is eligible to apply, how to apply, and available funding, please click here.
- conferences International conference "Biomembranes - 2018" at MIPT
Dear Colleagues! We are very pleased to invite you to participate in the International Conference “BIOMEMBRANES 2018”, which will be held on October 1-5, 2018 at the Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Moscow region, Russia.
- ys-ad Michael Gütschow lecture "Design and Synthesis of Novel Peptidomimetics as Inhibitors of Human Proteases"
September 7 (This event is over)
On Friday, September 7 at 14:00 in the Small Hall, the General Seminar of the IBCh RAS will be held. The lecture will be delivered by prof. Michael Gutchev from Bonn University, Germany.
- science news Seminar «Nutritional and pharmaceutical applications of bioactive compounds in plants»
August 6 (This event is over)
Dear colleagues, We invite you to the public seminar of Shela Gorinstein, Professor of Hebrew University of Jerusalem. It will take place on August 6 at 11 AM, in the conference hall on the 5th fl., IBCH RAS. The topic of the seminar is: «Nutritional and pharmaceutical applications of bioactive compounds in plants».
- science news The lecture by prof. Chandi C. Mandal Cancer biology basics. An intriguing link between cholesterol and tumorigenesis
August 2 (This event is over)
Thursday, 2 august, 15-00.Seminar room, bld. 34, stage 5. Chandi C. Mandal, PhD Associate Professor and Head Department of Biochemistry School of Life Sciences Central University of Rajasthan Dr. Mandal’s research interests: Finding the underlying molecular mechanism for cholesterol-induced cancer growth and Metastasis Investigating the molecular mechanism involved in cancer microcalcification and its prevention strategy Investigating the target identification for cold-mediated tumorigenesis Study for preventing mutation in mutation prone zones in cancer genome Identification of bioactive secondary metabolites for prevention of cancer metastasis Part 1. Cancer biology basics (15-00) Part 2. An intriguing link between cholesterol and tumorigenesis (15-40) Obesity, diabetes and hormonal imbalance have been linked with cancer incidence and/or mortality. Several findings have focused on high cholesterol as a cancer driving intrinsic factor. Although, this link has not yet been established well. This study aimed to find out whether elevation of cellular cholesterol promotes tumorigenesis. Our nationwide statistical analyses found an existence of positive correlation between cancer mortality rate and total average serum cholesterol of the population of a country. This positive relationship was also noticed in various anatomical site-specific cancers including thyroid, breast, ovary and others, except liver and cervical cancers. Moreover, tumor sample study found the higher expressions of cellular cholesterol regulatory genes (e.g. HMGCoR, LDLR) and elevated level of cholesterol in malignant breast cancer tissues as compared to benign tissues. Cell culture study documented that treatment of breast cancer cells with cholesterol increased cell proliferation and migration of breast cancer cells. Whereas, cholesterol depleting MBCD inhibited cell proliferation, EMT and stemness in breast cancer cells.
- ys-ad 48th Young Scientists Council Seminar "Rapid Prototyping: How to Simplify Daily Problems in Biochemistry and Biotechnology"
May 20–26 (This event is over)
On Friday, May 25 at 15:00 in the Small Hall, the Young Scientists Council Seminar devoted to the use of additive technologies in the context of a biological laboratory will be held.
- science news "Molecular Brain" seminar
May 25 (This event is over)
The seminar will take place on May 25 at 11:00 in the Minor hall. Professor Dmitri Rusakov from the Institute of Neurology, University College London (UK) will talk about synaptic microenvironment remodelling. Everyone is cordially invited.
- ys-ad Steffen Hering "Natural products as subunit specific modulators of GABAA receptors: From discovery to drug-development"
May 3–12 (This event is over)
On Friday, May 11th at 15:00 the Young Scientists Counsil seminar will host Univ. Prof. Dr. Steffen Hering, head of department of Pharmacology and Toxicology, University of Vienna.
- science news The 5 th International Congress on Microscopy & Spectroscopy (INTERM 2018)
April 24–30 (This event is over)
Dear Colleagues, On behalf of the Organizing Committee, we are pleased to invite you to take part in the “5th International Congress on Microscopy and Spectroscopy (INTERM)” which will be held on April 24-30, 2018 in the stunning Convention Centre of one of the largest international resort in Turkey right in the heart of Blue Lagoon (Oludeniz) area. INTERM is traditional annual congress for scientists and expected to collect a wide audience of participants and listeners. We are planning an outstanding scientific program led by world-renowned invited speakers, that will not only be a platform to showcase exciting new developments in microscopy and spectroscopy, but will also reveal the transformational role of microscopy in supporting a range of physical and life sciences. We hope that the scientific program, including a wide array of topics will live to your expectations, and that participation in the congress will offer you an opportunity to meet up with your colleagues, friends and renowned specialists from all over the world. We look forward to seeing you in Fethiye. INTERM Organizing Committee http://www.intermcongress.org/
- science news 5th Workshop on Molecular Neurobiology and Physiology "Current Methods in Physiology Research" dedicated to the 72nd anniversary of the birth of academician Eugene Grishin
April 20 (This event is over)
The workshop will take place on April 20 in the Minor hall. Talks will be made by world-leading scientists and representatives of high-tech entrepreneurship specializing in neurobiology. Everyone is cordially invited.
- science news A lecture by Prof. Alexey Terskikh "Signature of Glioblastoma Differentiation Revealed by Imaging of Epigenetic Landscapes” - April 20
April 20 (This event is over)
A lecture by Prof. Alexey Terskikh "Signature of Glioblastoma Differentiation Revealed by Imaging of Epigenetic Landscapes” will take place on Friday April 20th, 5 pm (seminar room, 5th floor, building 34).