Russian scientists together with colleagues from Sweden and the USA developed red fluorescent tags that are safe for nanoscopy in living cells. This work was funded by a grant from the Russian Science Foundation (RSF), and the results are published in Nature Methods journal.

One of the directions of the Molecular Technologies Laboratory is the development of new tools for bioimaging and optogenetics. Yulia Ermakova, Vsevolod Belousov and other lab members, in an article in Chemical Communications, describe a new member of SypHer family of genetically encoded pH indicators, SypHer3s.

Scientists from IBCh RAS together with foreign colleagues discovered that a toxin from the venom of the spider Heriaeus melloteei may serve as a hit in drug discovery for hypokalemic periodic paralysis type 2. The disease is caused by mutations in the gene encoding voltage-gated sodium channels NaV1.4, characteristic of skeletal muscles. As a result of the mutations, these channels conduct aberrant currents, the muscles are unable to respond to the signals of the nervous system, and weakness develops followed by paralysis. Until now, there is no reliable medication for all cases of this disease. The results of the work are published in the Proceedings of the National Academy of Sciences of the USA (PNAS).

Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH.

The Skoltech Center for Data Intensive Biomedicine and Biotechnology is proud to announce for the third time an open call for research fellowships in Systems Biology.  Application period: 20 February 2018 to 15 March 2018 (Deadline: 23:59, Moscow time). The total amount of support is 630,000 rubles per year. Period: 3-year. Deadline: 15-03-2018 23:59 For more information on who is eligible to apply, how to apply, and available funding, please click here.

Acting Director of the Institute of Bioorganic Chemistry RAS, President of the Russian Biochemistry and Molecular Biology Society, academician Alexander Gabibov and the head of the Pharmacology Department at Yale University, a member of the US National Academy of Sciences and a foreign member of the RAS, member of the International Advisory Board of Institute of Bioorganic Chemistry of the RAS Joseph Schlessinger on behalf of the President of the Russian Academy of Sciences awarded the Lomonosov Great Gold Medal to the laureate of 2016, Professor at Yale University, a member of the International Advisory Board of Institute of Bioorganic Chemistry RAS, Nobel Prize laureate Sidney Altman. Professor Altman has received the award "for outstanding contribution to the field of biochemistry of nucleic acids, the discovery of the catalytic activity of the nucleic acids and the creation of new biologically active substances."

The Joint Life Sciences Forum, including the International Scientific Conference in bioorganic chemistry "XII conference dedicated to the Memory of Academician Yuri A. Ovchinnikov" and the VIII Russian Symposium "Proteins and Peptides" with a Young Scientists Competition, was held at the Institute of Bioorganic Chemistry RAS at 18-22 September, 2017. The leading foreign experts who visited the forum named it one of the main scientific events in the field of Life Sciences in the world in this year.

Laboratory of Biological Tests of the Branch of the Institute of Bioorganic Chemistry (BICh) received an order from a European company for preclinical animal studies, which will be conducted in accordance with world standards. Thus, for the first time, Russia will export high-tech services such as pre-clinical research for foreign countries.

 Russian scientists together with foreign colleagues extended the shine time of fluorescent label in live cells. Light is emitted longer due to the continuous exchange of fluorogenic dyes interacting with special protein labels. The method which was described in the Chemical Science journal will simplify the live cells staining and provide new opportunities for research. This work was supported by the Russian Science Foundation.

Dear Colleagues! We are very pleased to invite you to participate in the International Conference “BIOMEMBRANES 2018”, which will be held on October 1-5, 2018 at the Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Moscow region, Russia.