- science news Scientists present a fully genetically encodable bioluminescent system
November 26, 2018
Scientists from Russia, UK, Spain, Brazil, Japan, and Austria discovered the essential set of enzymes that allows glowing fungi to emit light. The bioluminescent system includes a brand- new luciferase and three enzymes that enable biosynthesis of fungal luciferin from a widespread metabolite – caffeic acid – as well as its recycling. The genes encoding this “caffeic acid cycle” make up a unique molecular toolkit that allows to turn any higher organism into a glowing one. The work was published in Proceedings of the National Academy of Sciences of the United States of America.
- science news Kurt Wüthrich took part in the workshop of the Structural biology department
October 10, 2018
Professor Kurt Wüthrich, Nobel Laureate in Chemistry, 2002, visited Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS and took part in the workshop of the Structural biology department of the Institute (headed by Prof. Alexander Arseniev).
- science news Ras-dva: make regeneration great again
September 17, 2018
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- science news A bright bantam: BrUSLEE – green fluorescent protein with the unique properties
September 7, 2018
Researchers from the Biophotonics lab of IBCH RAS (Anastasia Mamontova, Konstantin Lukyanov and Alexey Bogdanov) designed a new green fluorescent protein that combines high fluorescence brightness and short fluorescence lifetime. They used a semi-rational protein evolution approach. Their collaborators from Bach Institute of Biochemistry and Semenov Institute of Physical Chemistry helped with the time-resolved fluorescence analysis (FLIM) that allowed characterizing the physical properties of this perspective probe. Research has recently been published in the Scientific Reports.
- science news Antibiotic from the bear's mouth
September 5, 2018
Scientists from the Laboratory of biocatalysis developed a new microfluidics-based ultrahigh-throughput technology for the “deep functional profiling” of microbial communities and used it to search for bacteria producing new antibiotics in the microbiome of the Siberian bear's oral cavity. This methodology allowed them not only to find the antibiotic amicoumacin, elucidating the mechanisms of its biosynthesis and self-resistance, but also to investigate the spectrum of its activity at the level of various bacterial communities. The results published in PNAS will find numerous applications in the field of antibiotic discovery and will help to solve the problem of antibiotic resistance.
- science news Visit of Delegation of Ministry of Science, Technology and Space of Israel
September 5, 2018
- science news Spider venom may help to stop neuronal death
August 20, 2018
Venoms of spiders and wasps contain acylpolyamines that act as high-affinity blockers of ionotropic receptors for glutamate, the main excitatory neurotransmitter in the human central nervous system (CNS). The first representative of acylpolyamines, argiopin from the venom of the orb-weaver spider Argiope lobata, was discovered in 1986 by Eugene Grishin’s team at IBCh RAS. Here, an international team of scientists, including a researcher from IBCh RAS, has used cryo-electron microscopy (cryo-EM) to determine the first atomic structure of an argiopin-glutamate receptor complex. This structure will help to design new drugs for treatment of neurodegenerative diseases. The study is published in Neuron.
- science news Fast and safe: new reversibly switchable fluorescent proteins for live-cell nanoscopy
July 10, 2018
Russian scientists together with colleagues from Sweden and the USA developed red fluorescent tags that are safe for nanoscopy in living cells. This work was funded by a grant from the Russian Science Foundation (RSF), and the results are published in Nature Methods journal.
- science news Genetically encoded fluorescent pH probe for precise monitoring of cellular biochemistry
May 3, 2018
One of the directions of the Molecular Technologies Laboratory is the development of new tools for bioimaging and optogenetics. Yulia Ermakova, Vsevolod Belousov and other lab members, in an article in Chemical Communications, describe a new member of SypHer family of genetically encoded pH indicators, SypHer3s.
- science news Spider venom will cure from paralysis
April 13, 2018
Scientists from IBCh RAS together with foreign colleagues discovered that a toxin from the venom of the spider Heriaeus melloteei may serve as a hit in drug discovery for hypokalemic periodic paralysis type 2. The disease is caused by mutations in the gene encoding voltage-gated sodium channels NaV1.4, characteristic of skeletal muscles. As a result of the mutations, these channels conduct aberrant currents, the muscles are unable to respond to the signals of the nervous system, and weakness develops followed by paralysis. Until now, there is no reliable medication for all cases of this disease. The results of the work are published in the Proceedings of the National Academy of Sciences of the USA (PNAS).
- science news "Molecular Brain" seminar
The seminar will take place on January 22 at 16:00 in the Minor hall. Professor Leonard Khiroug from the University of Helsinki (Finland) will talk about the "awake microscopy" methodology utilized for high-resolution brain imaging. Everyone is cordially invited.
- science news Lecture by Prof. Zhang Shuguang «The QTY Code: A tool for designing detergent-free membrane proteins»
December 24, 2018 (This event is over)
Prof. Zhang Shuguang from MIT will deliver a lecture entitled «The QTY Code: A tool for designing detergent-free membrane proteins». Date and time: Mon 24 December 2018 15:00. Location: Conference hall at 3rd floor BON IBCh.
- science news Lecture by Prof. Igor Roninson: «CDK8/19: a druggable mediator of transcriptional reprogramming»
December 17, 2018 (This event is over)
Prof. Igor Roninson from University of South Carolina will deliver a lecture entitled «CDK8/19: a druggable mediator of transcriptional reprogramming». Date and time: Mon 17 December 2018 11:00. Location: Conference hall at 3rd floor BON IBCh.
- science news Christmas meeting on neuroscience
December 13, 2018 (This event is over)
The meeting will take place on December 13 at 11:00 in the Minor hall. Talks will be presented by scientists from Russia, Canada, Finland, and Germany; the program is available on the IBCh website. Everyone is cordially invited.
- science news Russian-Israeli Mini-Symposium on Molecular Neurobiology
November 19, 2018 (This event is over)
The symposium will take place on November 19 at 10:00 in the Minor hall. Talks will be presented by scientists from Russia and Israel; the program is available on the IBCh website. Everyone is cordially invited.
- science news Marcus Conrad lecture "Ferroptosis: mechanisms and pharmacological amenability"
October 15, 2018 (This event is over)
Monday, October 15th, 15:00, Small Hall, Marcus Conrad (Institute of Developmental Genetics, Helmholtz Zentrum München) will give a talk "Ferroptosis: mechanisms and pharmacological amenability".
- conferences International conference "Biomembranes - 2018" at MIPT
October 1–5, 2018 (This event is over)
Dear Colleagues! We are very pleased to invite you to participate in the International Conference “BIOMEMBRANES 2018”, which will be held on October 1-5, 2018 at the Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Moscow region, Russia.
- ys-ad Michael Gütschow lecture "Design and Synthesis of Novel Peptidomimetics as Inhibitors of Human Proteases"
September 7, 2018 (This event is over)
On Friday, September 7 at 14:00 in the Small Hall, the General Seminar of the IBCh RAS will be held. The lecture will be delivered by prof. Michael Gutchev from Bonn University, Germany.
- science news Seminar «Nutritional and pharmaceutical applications of bioactive compounds in plants»
August 6, 2018 (This event is over)
Dear colleagues, We invite you to the public seminar of Shela Gorinstein, Professor of Hebrew University of Jerusalem. It will take place on August 6 at 11 AM, in the conference hall on the 5th fl., IBCH RAS. The topic of the seminar is: «Nutritional and pharmaceutical applications of bioactive compounds in plants».
- science news The lecture by prof. Chandi C. Mandal Cancer biology basics. An intriguing link between cholesterol and tumorigenesis
August 2, 2018 (This event is over)
Thursday, 2 august, 15-00.Seminar room, bld. 34, stage 5. Chandi C. Mandal, PhD Associate Professor and Head Department of Biochemistry School of Life Sciences Central University of Rajasthan Dr. Mandal’s research interests: Finding the underlying molecular mechanism for cholesterol-induced cancer growth and Metastasis Investigating the molecular mechanism involved in cancer microcalcification and its prevention strategy Investigating the target identification for cold-mediated tumorigenesis Study for preventing mutation in mutation prone zones in cancer genome Identification of bioactive secondary metabolites for prevention of cancer metastasis Part 1. Cancer biology basics (15-00) Part 2. An intriguing link between cholesterol and tumorigenesis (15-40) Obesity, diabetes and hormonal imbalance have been linked with cancer incidence and/or mortality. Several findings have focused on high cholesterol as a cancer driving intrinsic factor. Although, this link has not yet been established well. This study aimed to find out whether elevation of cellular cholesterol promotes tumorigenesis. Our nationwide statistical analyses found an existence of positive correlation between cancer mortality rate and total average serum cholesterol of the population of a country. This positive relationship was also noticed in various anatomical site-specific cancers including thyroid, breast, ovary and others, except liver and cervical cancers. Moreover, tumor sample study found the higher expressions of cellular cholesterol regulatory genes (e.g. HMGCoR, LDLR) and elevated level of cholesterol in malignant breast cancer tissues as compared to benign tissues. Cell culture study documented that treatment of breast cancer cells with cholesterol increased cell proliferation and migration of breast cancer cells. Whereas, cholesterol depleting MBCD inhibited cell proliferation, EMT and stemness in breast cancer cells.