Ann Rheum Dis, 2014, 73(10):1888-1897
HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE
Objective: Accumulation of mitochondria underlies T-cell dysfunction in systemic lupus erythematosus (SLE). Mitochondrial turnover involves endosomal traffic regulated by HRES-1/Rab4, a small GTPase that is overexpressed in lupus T cells. Therefore, we investigated whether (1) HRES-1/Rab4 impacts mitochondrial homeostasis and (2) Rab geranylgeranyl transferase inhibitor 3-PEHPC blocks mitochondrial accumulation in T cells, autoimmunity and disease development in lupusprone mice.
Scopus: 2-s2.0-84881126185
: 23897774
IBCH: 4279
Ссылка на статью в журнале: http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-203794
Кол-во цитирований на 04.2024: 121
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