Dokl Biochem Biophys, 2018, 483(1):326-328

The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase.

In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre-LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.

Bezborodova OA, Alekseenko IV, Nemtsova ER, Pankratov AA, Filyukova OB, Yakubovskaya RI, Kostina MB, Potapov VK, Sverdlov ED

IBCH: 7507
Ссылка на статью в журнале: http://link.springer.com/10.1134/S1607672918060091
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Данные статьи проверены модераторами 2018-11-01