Elena L. Vodovozova
Head of Laboratory (Laboratory of lipid chemistry)
After earning a Ph.D. thesis in Biochemistry (1985) related to the synthesis and application of photoactivatable lipid probes — a new trend of research at that time — she became a staff member of the Lab. In 2007, she presented a Dr. Chemistry thesis devoted to the developing of new photoaffinity lipid probes for the research in structural biology. From 2008 Dr. Vodovozova has headed the Lab of lipid chemistry.
|Period||Country, city||Education institution||Additional info|
|1976–1981||Russia, Moscow||M.V. Lomonosov Moscow State University (chemical faculty)||Ms in chemistry|
|1981–1985||Russia, Moscow||M.M. Shemyakin and Institute of Bioorganic Chemistry AS USSR||PhD in biochemistry|
|2007||Russia, Moscow||M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry RAS||DSc in chemistry|
Dr. Vodovozova has specialized in the design of targeted drug delivery systems (nanocarriers) on the basis of liposomes, lipid derivatives of anticancers (lipophilic prodrugs) and lipophilic glycoconjugates (vectors) from the middle of 1990 years. Another field of the research, which she has developed, relates to the synthesis of photoaffinity probes bearing new high-performance photophore — diazocyclopentadien-2-ylcarbonyl group.
Main scientific results
In collaboration with Russian and foreign colleagues, new data on membrane topography of cytochrome P-450 were received. Also, some aspects of knowledge on the mechanism of interleukin-2 receptor assembly in activated T-cells have been clarified, as well as fragments of interleukin-4 molecule involved in the interaction with ganglioside GM1 have been determined.
Dr. Vodovozova is the author of 66 research articles in Russian and international journals, as well as more than 100 abstracts at conferences, a book, a chapter in monograph, and 3 patents.