The unit was disbanded in 2018.

Laboratory of proteomics

Department of Peptide and Protein Technologies

Head: Vadim Govorun, member of the academy of sciences

proteome, peptidome, mass-spectrometry

Vadim Govorun, member of the academy of sciencesdepart.
Sergej Grachjov, Ph.D.s. r. f.+7(495)330-61-65
Rustam Ziganshin, Ph.D.s. r.
Vasilij Kadykov, D.Scs. r.
Dmitrij Klinov, Ph.D.s. r.
Anna Seredina, Ph.D.j. r. f.
Olga IvanovaPhD
Nikolay AnikanovPhD
Regina KhazigaleevaPhD
Elena PushkovaPhD stud.
Irina GagarinaPhD
Victor Demin,
Nataliya Logvina,
Igor' Azarkinres.

Former members:

Yury Kozmins. r.
Konstantin Mochalov, Ph.D.r.
Ekaterina Obraztsovar.
Igor Fesenko, Ph.D.r.
Andrey Knyazev, Ph.D.r.
Anna Mamaevar. f.
Sergej Kovalchuk, Ph.D.j. r.
Regina Azarkinaj. r. f.
Viktoria ShenderPhD
Galina Petrovat. q. - lab. as.
Veronika Manohinares. eng.
Aleksej Mezinres. eng.

Selected publications (show all)


Vadim Govorun

Alternative splicing shapes transcriptome but not proteome diversity in Physcomitrella patens (2017-12-05)

Alternative splicing (AS) can significantly impact the transcriptome and proteome of a eukaryotic cell. We analyzed the extent to which AS contributes to proteome diversity using moss Physcomitrella patens as a model object. We could distinguish a few examples that unambiguously indicated the presence of two or more splice isoforms from the same locus at the proteomic level. Our results indicate that alternative isoforms have a small effect on proteome diversity. We also revealed that mRNAs and pre-mRNAs have thousands of complementary binding sites for long non-coding RNAs (lncRNAs) that may lead to potential interactions in transcriptome. This finding points to an additional level of gene expression and AS regulation by non-coding transcripts in Physcomitrella patens.


  1. Fesenko I, Khazigaleeva R, Kirov I, Kniazev A, Glushenko O, Babalyan K, Arapidi G, Shashkova T, Butenko I, Zgoda V, Anufrieva K, Seredina A, Filippova A, Govorun V (2017). Alternative splicing shapes transcriptome but not proteome diversity in Physcomitrella patens. Sci Rep 7 (1), 2698