Bull Exp Biol Med, 2017, 163(4):430-435

Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning

We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield 30 mg/liter (90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.

IBCH: 3077
Ссылка на статью в журнале: http://link.springer.com/10.1007/s10517-017-3821-z
Кол-во цитирований на 11.2023: 3
Данные статьи проверены модераторами 2017-08-01