Eksp i Klin Farm, 2013, 76(9):22-26

Metabolic effects of delta-sleep inducing peptide during physiological ageing of the organism

Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 μg/100 g body weight favors normalization of the age-related changes in carbohydrate metabolism and shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats. The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.

Bondarenko TI, Maiboroda EA, Mikhaleva II, Prudchenko IA

IBCH: 4719
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