While dopamine is an established and a well-known signaling molecule and its biochemistry is widely studied, its derivatives remain underestimated (and largely unknown to) by the dopamine-researching community. Meanwhile, the fatty acid derivatives of dopamine and its precursors and metabolites were synthesized chemically already in 1991, and their in vivo existence in mammalian nervous system was show ten years thereafter. Shortly after the synthesis of N-arachidonoyl dopamine it was shown to exert various biological activities, including the participation of memory processes, pain transduction and immune response. The biochemical pathways of such compounds were drafted. However, their regulation mechanisms and exact enzymes are still to be discovered. The aim of this review is to draw attention of the dopamine-researching community to the fact that the action of dopamine is not limited to and ending with its existence as a stand-alone molecule. In the first part of an article the reader will be provided with a short history of N-acylated dopamines discovery. After that the current knowledge on the biochemistry of such compounds will be reviewed, including the discussion of the most promising topics for further research. Finally, the signals transduced by N-acyl dopamines will be discussed and special attention will be paid to the possible transformation and modulation of dopamine signal by such chemical conversion. © 2012 Nova Science Publishers, Inc.