Phospholipases A2 (PLA2s) compose a large protein superfamily with diverse biological activities. Some biological properties of PLA2 depend on enzymatic activity while some do not. Rat pheochromocytoma cells (PC12) can differentiate into neuron-like cells under some stimuli. PC12 are useful model for studying some “neuronal” effects, including anti-proliferative and differentiating ones, of various compounds. In this paper we summarize data on different aspects of PLA2 impact on PC12 and their involvment in some cellular events. PLA2s may stop proliferation and induce differentiation of PC12. They are involved in processes of cell death by several ways. PLA2s participate in exocytosis in PC12: they may take part in regulation of cell secretion and  may  be released by exocytosis. Biochemically, PLA2s interfere and/or interact with many other compounds: growth factors, toxic agents, calcium ions and so on. Most of the PLA2 effects on PC12 are now  considered as consequence of their phospholipase activity. However, some protein-protein interaction should not be rule out completely. Several striking findings have been made upon investigation of interaction of PLA2 and PC12 and we expect further exciting tidings in this area.