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Autologous T-Cell-Free Antigen Presentation System Unveils hCMV-Specific NK Cell Response
The scientists from the IBCh RAS proposed the autologous system of the hCMV-derived VMAPRTLFL (LFL) peptide stimulation without T lymphocytes and exogenous cytokines which allows to evaluate NK cell hCMV-specific responses. NK cells of individuals having high anti-hCMV-IgG levels, in contrast to NK cells of hCMV-seronegative and low-positive donors, displayed increased IFNγ production, degranulation and activation levels, and enhanced proliferation upon stimulation with the LFL peptide, presented in HLA-E. LFL-induced NK cell IFNγ production was dependent on PI3K and Ras/Raf/Mek signaling pathways. Transcriptomic profile of LFL-expanded NK cells showed increased adaptive gene expression and metabolic activation. This model may be further exploited for the identification of antigen-specific NK cells. The results are published in the Cells.
News
- Innovative Contact Lenses with Metal-Organic Frameworks for Glaucoma Treatment
science news
V.13 Researchers from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Harvard University, Sechenov University, the Pasteur Institute, and other scientific institutions in Russia and abroad have proposed a new method for controlling elevated intraocular pressure, which is a major damaging factor in glaucoma. They have developed a new type of contact lenses that incorporate metal-organic frameworks (MOFs) for the controlled and prolonged release of brimonidine, a medication used to reduce intraocular pressure. This innovation was presented in the high-ranking scientific journal Aggregate, highlighting its innovative nature and potential impact on ophthalmological practice.
- NMR spectroscopy reveals patterns and thermodynamic parameters of dimerization of β- hairpin antimicrobial peptides in the membrane
science news
IV.10 The staff of the Laboratory of structural biology of ion channels and the Science–Educational center for the first time studied the thermodynamics of the dimerization process of a β-hairpin peptide in the membrane-mimicking environment of detergent micelles using the example of the antimicrobial peptide (AMP) capitellacin of the marine polychaete Capitella teleta. The study also describes the mechanism of capitellacin action on bacterial membranes. The results of the work were published in the journal Biomolecules.
- Human RPF1 and ESF1 in Pre-rRNA Processing and Assembly of Pre-Ribosomal Particles: A Functional Study
science news
III.6 Ribosome biogenesis is a sophisticated time-ordered process, which adjusts the protein synthesis rate to consumption of nutrients and external stimuli. It begins with transcription of the ribosomal primary RNA precursor. 13.3 kB 47S (fig.) pre-rRNA processing is coupled with the sequential recruitment of ribosome biogenesis factors and non-coding RNAs as well as ordered coating of rRNA with ~80 ribosomal proteins during formation of the functional 60S and 40S ribosomal subunits.
Events
- "Molecular Brain" seminar
science news
IX.8.23 (This event is over) The seminar will take place on 08 September at 15:00 in the Minor hall. Professor Naira Ayvazyan, Director of the Orbeli Institute of Physiology of NAS RA (Yerevan, Armenia), will talk about the research conducted at this center. In particular, she will touch on the mechanisms of poisoning with snake venom. Everyone is cordially invited.