Коршун Владимир Аркадьевич

Образование

Период обученияСтрана, городУчебное заведениеДополнительная информация
1982–1989 Минск, СССР Белорусский государственный университет Диплом химика (с отличием)
1989–1992 Москва, СССР/Россия Аспирантура ИБХ АН СССР/РАН Диплом кандидата химических наук, 1993
2012 Москва, Россия ИБХ РАН Диплом доктора химических наук, 2012

Членство в научных обществах

Американское химическое общество

Член Учёного совета Института по изысканию новых антибиотиков им. Г.Ф. Гаузе РАМН

Гранты и проекты

ПериодДополнительная информация
1998–2000 Грант РФФИ 98-03-33017
2003–2005 Грант РФФИ 03-03-32196
2006–2007 Грант РФФИ 06-04-81019
2006–2008 Грант РФФИ 06-03-32426
2008–2008 Грант РФФИ 08-03-90900
2010–2012 Грант Программы "Молекулярная и клеточная биология" Президиума РАН
2010–2012 Грант РФФИ 10-04-00998
2013–2013 Грант РФФИ 13-04-90911
2013–2015 Грант РФФИ 13-04-01317
2015–2017 Грант РНФ 15-15-00053
2013–2017 Грант Программы "Молекулярная и клеточная биология" Президиума РАН
2016–2018 Грант РФФИ 16-04-01170

Избранные публикации

  1. Proskurin GV, Orlov AA, Brylev VA, Kozlovskaya LI, Chistov AA, Karganova GG, Palyulin VA, Osolodkin DI, Korshun VA, Aralov AV (2018). 3′-O-Substituted 5-(perylen-3-ylethynyl)-2′-deoxyuridines as tick-borne encephalitis virus reproduction inhibitors. Eur J Med Chem 155 (0), 77–83
  2. Jiang ZK, Tuo L, Huang DL, Osterman IA, Tyurin AP, Liu SW, Lukyanov DA, Sergiev PV, Dontsova OA, Korshun VA, Li FN, Sun CH (2018). Diversity, novelty, and antimicrobial activity of endophytic actinobacteria from mangrove plants in Beilun Estuary National Nature Reserve of Guangxi, China. Front Microbiol 9 (0), 868
  3. Hakobyan A, Galindo I, Nañez A, Arabyan E, Karalyan Z, Chistov AA, Streshnev PP, Korshun VA, Alonso C, Zakaryan H (2018). Rigid amphipathic fusion inhibitors demonstrate antiviral activity against African swine fever virus. J Gen Virol 99 (1), 148–156
  4. Speerstra S, Chistov AA, Proskurin GV, Aralov AV, Ulashchik EA, Streshnev PP, Shmanai VV, Korshun VA, Schang LM (2018). Antivirals acting on viral envelopes via biophysical mechanisms of action. Antiviral Res 149 (0), 164–173
  5. Alferova VA, Shuvalov MV, Suchkova TA, Proskurin GV, Aparin IO, Rogozhin EA, Novikov RA, Solyev PN, Chistov AA, Ustinov AV, Tyurin AP, Korshun VA (2018). 4-Chloro-l-kynurenine as fluorescent amino acid in natural peptides. Amino Acids  (0),
  6. Farzan VM, Ulashchik EA, Martynenko-Makaev YV, Kvach MV, Aparin IO, Brylev VA, Prikazchikova TA, Maklakova SY, Majouga AG, Ustinov AV, Shipulin GA, Shmanai VV, Korshun VA, Zatsepin TS (2017). Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters. Bioconjug Chem 28 (10), 2599–2607
  7. Aralov AV, Proskurin GV, Orlov AA, Kozlovskaya LI, Chistov AA, Kutyakov SV, Karganova GG, Palyulin VA, Osolodkin DI, Korshun VA (2017). Perylenyltriazoles inhibit reproduction of enveloped viruses. Eur J Med Chem 138 (0), 293–299
  8. Aparin IO, Proskurin GV, Golovin AV, Ustinov AV, Formanovsky AA, Zatsepin TS, Korshun VA (2017). Fine tuning of pyrene excimer fluorescence in molecular beacons by alteration of the monomer structure. J Org Chem 82 (19), 10015–10024
  9. Astakhova K, Golovin AV, Prokhorenko IA, Ustinov AV, Stepanova IA, Zatsepin TS, Korshun VA (2017). Design of 2′-phenylethynylpyrene excimer forming DNA/RNA probes for homogeneous SNP detection: The attachment manner matters. Tetrahedron 73 (23), 3220–3230
  10. Topolyan AP, Strizhevskaya DA, Belyaeva MA, Brylev VA, Ustinov AV, Formanovsky AA, Korshun VA (2016). A triphenylcyclopropenylium mass tag: Synthesis and application to ultrasensitive LC/MS analysis of amines. Analyst (Lond) 141 (11), 3289–3295
  11. Aparin IO, Farzan VM, Veselova OA, Chistov AA, Podkolzin AT, Ustinov AV, Shipulin GA, Formanovsky AA, Korshun VA, Zatsepin TS (2016). 1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay. Analyst (Lond) 141 (4), 1331–1338
  12. Ponomarenko AI, Brylev VA, Nozhevnikova EV, Korshun VA (2015). Recent advances in self-assembled fluorescent DNA structures and probes. Curr Top Med Chem 15 (13), 1162–1178
  13. Топольян АП, Стрижевская ДА, Слюндина МС, Беляева МА, Иванова ОМ, Коршун ВА, Устинов АВ, Михура ИВ, Формановский АА (2015). Дериватизация первичных аминов катионом трис(2,6-диметоксифенил)метилия для анализа методом масс-спектрометрии МАЛДИ. 12 (4), 253–258
  14. Ryazantsev , Kvach , Tsybulsky , Prokhorenko , Stepanova , Martynenko , Gontarev , Shmanai , Zavriev , Korshun  (2014). Design of molecular beacons: 3′ couple quenchers improve fluorogenic properties of a probe in real-time PCR assay. Analyst, 139 (11), 2867–2872 (2014). Analyst (Lond) 139 (11), 2867–2872
  15. Fomich MA, Kvach MV, Navakouski MJ, Weise C, Baranovsky AV, Korshun VA, Shmanai VV (2014). Azide phosphoramidite in direct synthesis of azide-modified oligonucleotides. Org Lett 16 (17), 4590–4593
  16. Aparin IO, Chistov AA, Prokhorenko IA, Stepanova IA, Veselova OA, Ustinov AV, Formanovsky AA, Zatsepin TS, Korshun VA (2014). Blue-emitting fluorescent azides for DNA labelling. 14 (0), 222–224
  17. Topolyan AP, Brylev VA, Ustinov AV, Formanovsky AA, Korshun VA (2014). Carbocationic mass tags for information encoding and multiplex bioanalytical applications. 25 (0), 123
  18. Mikhaleva , Glybin , Guz , Streshnev , Kutyakov , Mikhura , Korshun , Ustinov , Chistov  (2014). Base-modified pyrenebutadiynyl nucleosides. 14 (0), 222–224
  19. Ryazantsev DY, Kvach MV, Tsybulsky DA, Prokhorenko IA, Stepanova IA, Martynenko YV, Gontarev SV, Shmanai VV, Zavriev SK, Korshun VA (2014). Design of molecular beacons: 3’ couple quenchers improve fluorogenic properties of a probe in real-time PCR assay. Analyst (Lond) 139 (11), 2867–2872
  20. Colpitts CC, Ustinov AV, Epand RF, Epand RM, Korshun VA, Schanga LM (2013). 5-(perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses. J Virol 87 (7), 3640–3654
  21. Astakhova IK, Santhosh Kumar T, Campbell MA, Ustinov AV, Korshun VA, Wengel J (2013). Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2′-α-l-amino-LNA FRET pairs. Chem Commun (Camb) 49 (5), 511–513
  22. Osterman IA, Ustinov AV, Evdokimov DV, Korshun VA, Sergiev PV, Serebryakova MV, Demina IA, Galyamina MA, Govorun VM, Dontsova OA (2013). A nascent proteome study combining click chemistry with 2DE. Proteomics 13 (1), 17–21
  23. Ryazantsev DY, Tsybulsky DA, Prokhorenko IA, Kvach MV, Martynenko YV, Philipchenko PM, Shmanai VV, Korshun VA, Zavriev SK (2012). Two-dye and one- or two-quencher DNA probes for real-time PCR assay: Synthesis and comparison with a TaqMan™ probe. Anal Bioanal Chem 404 (1), 59–68
  24. Tsybulsky DA, Kvach MV, Stepanova IA, Korshun VA, Shmanai VV (2012). 4',5'-Dichloro-2',7'-dimethoxy-5(6)-carboxyfluorescein (JOE): Synthesis and spectral properties of oligonucleotide conjugates. J Org Chem 77 (2), 977–984
  25. Kocherginskaya PB, Romanova AV, Prokhorenko IA, Itkis DM, Korshun VA, Goodilin EA, Tretyakov YD (2011). Modification of quantum dots with nucleic acids. RUSS CHEM REV 80 (12), 1209–1221
  26. Astakhova IV, Ustinov AV, Korshun VA, Wengel J (2011). LNA for optimization of fluorescent oligonucleotide probes: Improved spectral properties and target binding. Bioconjug Chem 22 (4), 533–539
  27. Astakhova IV, Lindegaard D, Korshun VA, Wengel J (2010). Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: High-affinity hybridization and fluorescence sensing. Chem Commun (Camb) 46 (44), 8362–8364
  28. St Vincent MR, Colpitts CC, Ustinov AV, Muqadas M, Joyce MA, Barsby NL, Epand RF, Epand RM, Khramyshev SA, Valueva OA, Korshun VA, Tyrrell DLJ, Schang LM (2010). Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses. Proc Natl Acad Sci U S A 107 (40), 17339–17344
  29. Kvach MV, Stepanova IA, Prokhorenko IA, Stupak AP, Bolibrukh DA, Korshun VA, Shmanai VV (2009). Practical synthesis of isomerically pure 5- and 6- carboxytetramethylrhodamines, useful dyes for DNA probes. Bioconjug Chem 20 (8), 1673–1682
  30. Astakhova IV, Korshun VA, Wengel J (2008). Highly fluorescent conjugated pyrenes in nucleic acid probes: (Phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids. Chemistry 14 (35), 11010–11026
  31. Ustinov AV, Shmanai VV, Patel K, Stepanova IA, Prokhorenko IA, Astakhova IV, Malakhov AD, Skorobogatyi MV, Bernad PL, Khan S, Shahgholi M, Southern EM, Korshun VA, Shchepinov MS (2008). Reactive trityl derivatives: Stabilised carbocation mass-tags for life sciences applications. Org Biomol Chem 6 (24), 4593–4608
  32. Filichev VV, Astakhova IV, Malakhov AD, Korshun VA, Pedersen EB (2008). 1-, 2-, and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids: Structure, thermal stability, and fluorescence relationship. Chemistry 14 (32), 9968–9980
  33. Astakhova IV, Korshun VA, Jahn K, Kjems J, Wengel J (2008). Perylene attached to 2′-amino-LNA: Synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture. Bioconjug Chem 19 (10), 1995–2007
  34. Kvach MV, Ustinov AV, Stepanova IA, Malakhov AD, Skorobogatyi MV, Shmanai VV, Korshun VA (2008). A convenient synthesis of cyanine dyes: Reagents for the labeling of biomolecules. European J Org Chem  (12), 2107–2117
  35. Birikh KR, Korshun VA, Bernad PL, Malakhov AD, Milner N, Khan S, Southern EM, Shchepinov MS (2008). Novel mass tags for single nucleotide polymorphism detection. Anal Chem 80 (7), 2342–2350
  36. Ustinov AV, Dubnyakova VV, Korshun VA (2008). A convenient 'click chemistry' approach to perylene diimide-oligonucleotide conjugates. Tetrahedron 64 (7), 1467–1473
  37. Lindegaard D, Madsen AS, Astakhova IV, Malakhov AD, Babu BR, Korshun VA, Wengel J (2008). Pyrene-perylene as a FRET pair coupled to the N2′-functionality of 2′-amino-LNA. Bioorg Med Chem 16 (1), 94–99
  38. Astakhova IV, Malakhov AD, Stepanova IA, Ustinov AV, Bondarev SL, Paramonov AS, Korshun VA (2007). 1-Phenylethynylpyrene (1-PEPy) as refined excimer forming alternative to pyrene: Case of DNA major groove excimer. Bioconjug Chem 18 (6), 1972–1980
  39. Kvach MV, Tsybulsky DA, Ustinov AV, Stepanova IA, Bondarev SL, Gontarev SV, Korshun VA, Shmanai VV (2007). 5(6)-Carboxyfluorescein revisited: New protecting group, separation of isomers, and their spectral properties on oligonucleotides. Bioconjug Chem 18 (5), 1691–1696
  40. Prokhorenko IA, Malakhov AD, Kozlova AA, Momynaliev K, Govorun VM, Korshun VA (2006). Phenylethynylpyrene-labeled oligonucleotide probes for excimer fluorescence SNP analysis of 23S rRNA gene in clarithromycin-resistant Helicobacter pylori strains. Mutat Res 599 (12), 144–151
  41. Dioubankova NN, Malakhov AD, Stetsenko DA, Gait MJ, Korshun VA (2006). Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides. Tetrahedron 62 (29), 6762–6773
  42. Skorobogatyi MV, Malakhov AD, Pchelintseva AA, Turban AA, Bondarev SL, Korshun VA (2006). Fluorescent 5-alkynyl-2′-deoxyuridines: High emission efficiency of a conjugated perylene nucleoside in a DNA duplex. Chembiochem 7 (5), 810–816
  43. Skorobogatyi MV, Ustinov AV, Stepanova IA, Pchelintseva AA, Petrunina AL, Andronova VL, Galegov GA, Malakhov AD, Korshun VA (2006). 5-Arylethynyl-2′-deoxyuridines, compounds active against HSV-1. Org Biomol Chem 4 (6), 1091–1096
  44. Skorobogatyi MV, Pchelintseva AA, Petrunina AL, Stepanova IA, Andronova VL, Galegov GA, Malakhov AD, Korshun VA (2006). 5-Alkynyl-2′-deoxyuridines, containing bulky aryl groups: Evaluation of structure-anti-HSV-1 activity relationship. Tetrahedron 62 (6), 1279–1287
  45. Bernad PL, Khan S, Korshun VA, Southern EM, Shchepinov MS (2005). S(O)-pixyl protecting group as efficient mass-tag. Chem Commun (Camb)  (27), 3466–3468
  46. Dioubankova NN, Malakhov AD, Shenkarev ZO, Korshun VA (2004). Oligonucleotides containing new fluorescent 1-phenylethynylpyrene and 9,10-bis(phenylethynyl)anthracene uridine-2′-carbamates: Synthesis and properties. Tetrahedron 60 (21), 4617–4626
  47. Malakhov AD, Skorobogatyi MV, Prokhorenko IA, Gontarev SV, Kozhich DT, Stetsenko DA, Stepanova IA, Shenkarev ZO, Berlin YA, Korshun VA (2004). 1-(Phenylethynyl)pyrene and 9,10-bis(phenylethynyl)anthracene, useful fluorescent dyes for DNA labeling: Excimer formation and energy transfer. European J Org Chem  (6), 1298–1307
  48. Dioubankova NN, Malakhov AD, Stetsenko DA, Gait MJ, Volynsky PE, Efremov RG, Korshun VA (2003). Pyrenemethyl ara-uridine-2′-carbamate: A strong interstrand excimer in the major groove of a DNA duplex. Chembiochem 4 (9), 841–847
  49. Shchepinov MS, Korshun VA (2003). Recent applications of bifunctional trityl groups. Chem Soc Rev 32 (3), 170–180
  50. Dioubankova NN, Malakhov AD, Stetsenko DA, Korshun VA, Gait MJ (2002). (R)-2,4-Dihydroxybutyramide seco-Pseudonucleosides: New Versatile Homochiral Synthons for Synthesis of Modified Oligonucleotides. Org Lett 4 (26), 4607–4610
  51. Malakhov AD, Prokhorenko IA, Kuznitsova SV, Skorobogatyi MV, Korshun VA, Berlin YA (2001). Synthesis of a new fluorescent 9,10-bisphenylethynylanthracene-derived pseudonucleoside and its introduction into oligonucleotides. Bioorg Khim 25 (12), 933–937
  52. Prokhorenko IA, Korshun VA, Berlin YA (2001). Fluorescence resonance energy transfer in nucleic acid research. Bioorg Khim 25 (11), 838–847
  53. Malakhov AD, Korshun VA, Berlin YA (2001). Synthesis and fluorescent characteristics of oligodeoxynucleotides containing a novel fluorescent label, p-(2-benzoxazolyl)tolane. Bioorg Khim 27 (6), 465
  54. Malakhov AD, Malakhova EV, Kuznitsova SV, Grechishnikova IV, Prokhorenko IA, Skorobogatyi MV, Korshun VA, Berlin YA (2000). Synthesis and fluorescent properties of 5-(1-pyrenylethynyl)-2′-deoxyuridine-containing oligodeoxynucleotides. Bioorg Khim 26 (1), 48–50
  55. Balakin KV, Korshun VA, Mikhalev II, Maleev GV, Malakhov AD, Prokhorenko IA, Berlin YA (1999). Erratum: Conjugates of oligonucleotides with polyaromatic fluorophores as promising DNA probes (Biosensors and Bioelectronics 13 (1998) (771-778) PII: S0956566398000414). Biosens Bioelectron 14 (6), 597
  56. Malakhova EV, Malakhov AD, Kuznitsova SV, Varnavskii OP, Kadutskii AP, Kozhich DT, Korshun VA, Berlin YA (1998). Reagents for Introducing a Fluorescent Deoxyuridine 2-Phenylbenzoxazole Derivative into Oligonucleotides. Bioorg Khim 24 (9), 694–695
  57. Balakin KV, Korshun VA, Mikhalev II, Maleev GV, Malakhov AD, Prokhorenko IA, Berlin YA (1998). Conjugates of oligonucleotides with polyaromatic fluorophores as promising DNA probes. Biosens Bioelectron 13 (78), 771–778
  58. Korshun VA, Manasova EV, Balakin KV, Prokhorenko IA, Buchatskii AG, Berlin YA (1996). 5-(1-Pyrenylethynyl)-2′-Deoxyuridine, a Novel Fluorescent Nucleoside Analogue. Bioorg Khim 22 (12),
  59. Prokhorenko IA, Korshun VA, Petrov AA, Gontarev SV, Berlin YA (1995). Incorporation of a pyrene nucleoside analogue into synthetic oligodeoxynucleotides using a nucleoside-like synthon. Bioorg Med Chem Lett 5 (18), 2081–2084
  60. Korshun VA, Pestov NB, Birikh KR, Berlin YA (1992). Reagent for Introducing Pyrene Residues in Oligonucleotides. Bioconjug Chem 3 (6), 559–562