Genomic Analysis and Correction Group
|Natal'ja Patrusheva||res. eng.|
The PTENP1 pseudogene is methylated in normal endometrium as well as in endometrial hyperplasias and carcinomas in middle aged and elderly females
It was demonstrated that the bidirectional promoter of the PTENP1 pseudogene was methylated at a high frequency in all studied endometrial tissues, except for the normal endometrium of young females (17 - 34 years). We think that PTENP1 pseudogene methylation reflects the age related changes in the human body and may not be directly related to the endometrial cancer or endometrial hyperplasia.