Жмак Максим Нургаянович

Кандидат химических наук


Старший научный сотрудник (Лаборатория лиганд-рецепторных взаимодействий)

Тел.: +7 (495) 330-73-74

Эл. почта: mzhmak@gmail.com

Избранные публикации

  1. Dubovskii PV, Ignatova AA, Volynsky PE, Ivanov IA, Zhmak MN, Feofanov AV, Efremov RG (2018). Improving therapeutic potential of antibacterial spider venom peptides: coarse-grain molecular dynamics guided approach. Future Med Chem 10 (19), 2309–2322
  2. Shelukhina IV, Zhmak MN, Lobanov AV, Ivanov IA, Garifulina AI, Kravchenko IN, Rasskazova EA, Salmova MA, Tukhovskaya EA, Rykov VA, Slashcheva GA, Egorova NS, Muzyka IS, Tsetlin VI, Utkin YN (2018). Azemiopsin, a selective peptide antagonist of muscle nicotinic acetylcholine receptor: Preclinical evaluation as a local muscle relaxant. Toxins (Basel) 10 (1),
  3. Kasheverov IE, Chugunov AO, Kudryavtsev DS, Ivanov IA, Zhmak MN, Shelukhina IV, Spirova EN, Tabakmakher VM, Zelepuga EA, Efremov RG, Tsetlin VI (2016). High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method. Sci Rep 6 (0), 36848
  4. Vulfius CA, Spirova EN, Serebryakova MV, Shelukhina IV, Kudryavtsev DS, Kryukova EV, Starkov VG, Kopylova NV, Zhmak MN, Ivanov IA, Kudryashova KS, Andreeva TV, Tsetlin VI, Utkin YN (2016). Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors. Toxicon 121 (0), 70–76
  5. Kasheverov IE, Kryukova EV, Kudryavtsev DS, Ivanov IA, Egorova NV, Zhmak MN, Spirova EN, Shelukhina IV, Odinokov AV, Alfimov MV, Tsetlin VI (2016). Analysis of binding centers in nicotinic receptors with the aid of synthetic peptides. Dokl Biochem Biophys 470 (1), 338–341
  6. Zakharova GV, Konstantinov RR, Odinokov AV, Chibisov AK, Alfimov MV, Kasheverov IE, Utkin YN, Zhmak MN, Tsetlin VI (2016). Effect of a peptide modeling the nicotinic receptor binding site on the spectral and luminescent properties of dye complexes with cucurbit[8]uril. HIGH ENERG CHEM+ 50 (2), 121–126
  7. Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN (2015). Neurotoxins from snake venoms and α-Conotoxin ImI inhibit functionally active Ionotropic γ-aminobutyric acid (GABA) receptors. J Biol Chem 290 (37), 22747–22758
  8. Kudryavtsev D, Shelukhina I, Vulfius C, Makarieva T, Stonik V, Zhmak M, Ivanov I, Kashevero I, Utkin Y, Tsetlin V (2015). Natural compounds interacting with nicotinic acetylcholine receptors: From low-molecular weight ones to peptides and proteins. Toxins (Basel) 7 (5), 1683–1701
  9. Kasheverov IE, Kudryavtsev DS, Ivanov IA, Zhmak MN, Chugunov AO, Tabakmakher VM, Zelepuga EA, Efremov RG, Tsetlin VI (2015). Rational design of new ligands for nicotinic receptors on the basis of α-conotoxin PnIA. Dokl Biochem Biophys 461 (1), 106–109
  10. Pinegin BV, Pashenkov MV, Kulakov VV, Murugin VV, Zhmak MN (2015). Complexes of DNA with the Antimicrobial Peptide LL37 Augment NK Cell Functions by Inducing Type i Interferon Production from Circulating Monocytes and Plasmacytoid Predendritic Cells. J Interferon Cytokine Res 35 (11), 850–858
  11. Lykhmus O, Gergalova G, Koval L, Zhmak M, Komisarenko S, Skok M (2014). Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction. Int J Biochem Cell Biol 53 (0), 246–252
  12. Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SCR, Tsetlin VI (2012). Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem 287 (32), 27079–27086
  13. Surin AM, Kryukova EV, Strukov AS, Zhmak MN, Talka R, Tuominen R, Salminen O, Khiroug LS, Kasheverov IE, Tsetlin VI (2012). The effect of MII α-conotoxin and its N-terminal derivatives on Ca2+- and Na+-signals induced by nicotine in SH-SY5Y neuroblastoma cells. Russ. J. Bioorganic Chem. 38 (2), 184–191
  14. Kasheverov IE, Zhmak MN, Khruschov AY, Tsetlin VI (2011). Design of new α-conotoxins: From computer modeling to synthesis of potent cholinergic compounds. Mar Drugs 9 (10), 1698–1714
  15. Koval L, Lykhmus O, Zhmak M, Khruschov A, Tsetlin V, Magrini E, Viola A, Chernyavsky A, Qian J, Grando S, Komisarenko S, Skok M (2011). Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro. Int J Biochem Cell Biol 43 (4), 516–524
  16. MacHáň R, Hof M, Chernovets T, Zhmak MN, Ovchinnikova TV, Sýkora J (2011). Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS. Anal Bioanal Chem 399 (10), 3547–3554
  17. Kasheverov IE, Zhmak MN, Fish A, Rucktooa P, Khruschov AY, Osipov AV, Ziganshin RH, DHoedt D, Bertrand D, Sixma TK, Smit AB, Tsetlin VI (2009). Interaction of α-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: Additional binding sites on Torpedo receptor. J Neurochem 111 (4), 934–944
  18. Ovchinnikova TV, Shenkarev ZO, Nadezhdin KD, Balandin SV, Zhmak MN, Kudelina IA, Finkina EI, Kokryakov VN, Arseniev AS (2007). Recombinant expression, synthesis, purification, and solution structure of arenicin. Biochem Biophys Res Commun 360 (1), 156–162
  19. Koroev DO, Titova MA, Volkova TD, Oboznaya MB, Filatova MP, Fufacheva EN, Zhmak MN, Tsetlin VI, Bobkova NV, VolPina OM (2007). Induction of antibodies to particular sites of the α7 subunit of the nicotinic acetylcholine receptor in mice of different lines. Russ. J. Bioorganic Chem. 33 (4), 410–414
  20. Vassilevski AA, Kozlov SA, Zhmak MN, Kudelina IA, Dubovskii PV, Shatursky OY, Arseniev AS, Grishin EV (2007). Synthetic analogues of antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi. Russ. J. Bioorganic Chem. 33 (4), 376–382
  21. Kasheverov IE, Zhmak MN, Vulfius CA, Gorbacheva EV, Mordvintsev DY, Utkin YN, Van Elk R, Smit AB, Tsetlin VI (2006). α-Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californica and some neuronal subtypes of nicotinic acetylcholine receptors. FEBS J 273 (19), 4470–4481
  22. Tsetlin VI, Kasheverov IE, Zhmak MN, Utkin YN, Vulfius CA, Smit AB, Bertrand D (2006). α-conotoxin analogs with enhanced affinity for nicotinic receptors and acetylcholine-binding proteins. J Mol Neurosci 30 (12), 77–78
  23. Shelukhina IV, Kryukova EV, Skok MV, Lykhmus EY, Zhmak MN, Mordvintsev DY, Kasheverov IE, Tsetlin VI (2006). Analysis of specificity of antibodies against synthetic fragments of different neuronal nicotinic acetylcholine receptor subunits. Biochemistry (Mosc) 71 (7), 749–758
  24. Kasheverov IE, Chiara DC, Zhmak MN, Maslennikov IV, Pashkov VS, Arseniev AS, Utkin YN, Cohen JB, Tsetlin VI (2006). α-conotoxin GI benzoylphenylalanine derivatives 1H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor. FEBS J 273 (7), 1373–1388
  25. Volpina OM, Titova MA, Koroev DO, Volkova TD, Oboznaya MB, Zhmak MN, Aleekseev TA, Tsetlin VI (2006). Production of antibodies to the α7-subunit of human acetylcholine receptor with the use of immunoactive synthetic peptides. Russ. J. Bioorganic Chem. 32 (2), 154–159
  26. Celie PHN, Kasheverov IE, Mordvintsev DY, Hogg RC, Van Nierop P, Van Elk R, Van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB (2005). Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant. Nat Struct Mol Biol 12 (7), 582–588
  27. Kotelnikova OV, Chibiskova OV, Nesmeyanov VA, Alliluev AP, Volpina OV, Koroev DO, Zhmak MN, Titova MA, Ivanov VT (2005). Protective properties of synthetic peptides of outer meningococcal membrane. Bull Exp Biol Med 139 (5), 593–595
  28. Koval OM, Voitenko LP, Skok MV, Lykhmus EY, Tsetlin VI, Zhmak MN, Skok VI (2004). The β-subunit composition of nicotinic acetylcholine receptors in the neurons of the guinea pig inferior mesenteric ganglion. Neurosci Lett 365 (2), 143–146
  29. Oboznaya MB, Volpina OM, Zhmak MN, Titova MA, Volkova TD, Egorov AA, Rybakov SS, Ivanov VT (2004). Induction of immune response by synthetic fragments of the bovine prion protein and their analogues in mice of various lines. Russ. J. Bioorganic Chem. 30 (4), 320–326
  30. Dubovskii PV, Zhmak MN, Maksaev GI, Arseniev AS (2004). A new water-soluble analogue of the fusion peptide of influenza virus hemagglutinin: Synthesis and properties. Russ. J. Bioorganic Chem. 30 (2), 196–198
  31. Dubovskiǐ PV, Zhmak MN, Maksaev GI, Arsenev AS (2004). New water-soluble analog of the fusion peptide of influenza virus hemagglutinin: synthesis and properties. Bioorg Khim 30 (2), 221–223
  32. Kasheverov IE, Zhmak MN, Maslennikov IV, Utkin YN, Tsetlin VI (2003). A comparative study on selectivity of α-conotoxins GI and ImI using their synthetic analogues and derivatives. Neurochem Res 28 (34), 599–606
  33. Volpina OM, Titova MA, Zhmak MN, Koroev DO, Oboznaya MB, Volkova TD, Ivanov VT (2002). Structure prediction for peptides capable of inducing antibody formation in mice. Bioorg Khim 28 (5), 394–395
  34. Koroev DO, Oboznaya MB, Zhmak MN, Volkova TD, Titova MA, Kotelnikova OV, Lakhtina OE, Volpina OM, Nesmeyanov VA, Alliluev AP, Ivanov VT (2002). Induction of antimeningitis immunity by synthetic peptides. III. Immunoactive synthetic fragments of the NspA protein from Neisseria meningitidis. Bioorg Khim 28 (4), 296–297
  35. Koroev DO, Oboznaya MB, Zhmak MN, Volkova TD, Titova MA, Kotelnikova OV, Lakhtina OE, Volpina OM, Nesmeyanov VA, Alliluev AP, Ivanov VT (2002). Induction of antimeningitis immunity by synthetic peptides: III. Immunoactive synthetic fragments of the NspA protein from Neisseria meningitidis. Russ. J. Bioorganic Chem. 28 (4), 263–268
  36. Kasheverov IE, Rozhkova AM, Zhmak MN, Utkin YN, Tsetlin VI (2002). Photoactivatable analogues of α-conotoxins GI and MI and their interaction with nicotinic acetylcholine receptor. Russ. J. Bioorganic Chem. 28 (2), 86–92
  37. Kasheverov IE, Rozhkova AM, Zhmak MN, Utkin YN, Tsetlin VI (2002). Photoactivatable analogues of α-conotoxins GI and MI and their interaction with nicotinic acetylcholine receptor. Bioorg Khim 28 (2), 107–108
  38. Volpina OM, Titova MA, Zhmak MN, Koroev DO, Oboznaya MB, Volkova TD, Ivanov VT (2002). Structure prediction for peptides capable of inducing antibody formation in mice. Russ. J. Bioorganic Chem. 28 (5), 349–356
  39. Zhmak MN, Kasheverov IE, Utkin YN, Tsetlin VI, Volpina OM, Ivanov VT (2001). An Efficient Synthetic Scheme for Natural α-Conotoxins and Their Analogues. Russ. J. Bioorganic Chem. 27 (2), 67–71
  40. Volkova TD, Volpina OM, Zhmak MN, Ivanov VT, Vorovich MF, Timofeev AV (2001). Synthesis, Immunogenicity, and Antigenicity of the Glycoprotein E Fragments of the Tick-Borne Encephalitis Virus. Russ. J. Bioorganic Chem. 27 (3), 151–155
  41. Zhmak MN, Kasheverov IE, Utkin YN, Tsetlin VI, Volpina OM, Ivanov VT (2001). An efficient synthetic scheme for natural α-conotoxins and their analogues. Bioorg Khim 27 (2), 87–88
  42. Koroev DO, Volpina OM, Zhmak MN, Kupriyanova MA, Nesmeyanov VA, Alliluev AP, Kotelnikova OV, Ivanov VT (2001). Induction of antimeningitis immunity by synthetic peptides. II. Immunoactive synthetic fragments of the OpaB protein from Neisseria meningitidis. Bioorg Khim 27 (1), 26
  43. Koroev DO, Volpina OM, Zhmak MN, Kupriyanova MA, Nesmeyanov VA, Alliluev AP, Kotelnikova OV, Ivanov VT (2001). Induction of Anti-Meningitis Immunity by Synthetic Peptides: II. Immunoactive Synthetic Fragments of the OpaB Protein from Neisseria meningitidis. Russ. J. Bioorganic Chem. 27 (1), 17–22
  44. Volpina OM, Zhmak MN, Oboznaya MB, Titova MA, Koroev DO, Volkova TD, Egorov AA, Rybakov SS, Ivanov VT (2001). Antibodies against Synthetic Fragments of the Prion Protein for Diagnostics of Bovine Spongiform Encephalopathy. Russ. J. Bioorganic Chem. 27 (5), 311–317
  45. Zolotarev YA, Bocharov EV, Dadayan AK, Kasheverov IE, Zhmak MN, Maslennikov IV, Borisov YA, Arseniev AS, Myasoedov NF, Tsetlin VI (2001). The solid-state catalytic isotope exchange of hydrogen in α-conotoxin G1 by the tritium spillover. Bioorg Khim 26 (8), 591–592
  46. Kuprianova MA, Zhmak MN, Koroev DO, Chepurkin AV, Volpina OM, Ivanov VT (2001). Synthetic peptide constructs on the basis of immunoactive fragments of the A22 strain VP1 of the foot-and-mouth disease virus. Bioorg Khim 26 (12), 932
  47. Kasheverov I, Rozhkova A, Zhmak M, Utkin Y, Ivanov V, Tsetlin VI (2001). Photoactivatable α-conotoxins reveal contacts with all subunits as well as antagonist-induced rearrangements in the Torpedo californica acetylcholine receptor. 268 (13), 3664–3673
  48. Zhmak MN, Kasheverov IE, Utkin IN, Tsetlin VI, Volpina OM, Ivanov VT (2001). Efficient synthesis of natural alpha-conotoxins and their analogs. Bioorg Khim 27 (2), 83–88
  49. Volkova TD, Volpina OM, Zhmak MN, Ivanov VT, Vorovich MF, Timofeev AV (2001). Synthesis, immunogenicity, and antigenicity of the glycoprotein E fragments of the tick-borne encephalitis virus. Bioorg Khim 27 (3), 179
  50. Volpina OM, Zhmak MN, Oboznaya MB, Titova MA, Koroev DO, Volkova TD, Egorov AA, Rybakov SS, Ivanov VT (2001). Antibodies against synthetic fragments of the prion protein for diagnostics of bovine spongiform encephalopathy. Bioorg Khim 27 (5), 358
  51. Kuprianova MA, Zhmak MN, Koroev DO, Chepurkin AV, Volpina OM, Ivanov VT (2000). Synthetic peptide constructs on the basis of immunoactive fragments of the A22 strain \pl of the foot-and-mouth disease virus. Bioorg Khim 26 (12), 926–932
  52. Zolotarev YA, Bocharov EV, Dadayan AK, Kasheverov IE, Zhmak MN, Maslennikov IV, Borisov YA, Arseniev AS, Myasoedov NF, Tsetlin VI (2000). The solid-state catalytic isotope exchange of hydrogen in α-conotoxin G1 by the tritium spillover. Bioorg Khim 26 (8), 587–592
  53. Zolotarev YA, Bocharov EV, Dadayan AK, Kasheverov IE, Zhmak MN, Maslennikov IV, Borisov YA, Arseniev AS, Myasoedov NF, Tsetlin VI (2000). The solid-state catalytic isotope exchange of hydrogen in α-conotoxin G1 by the tritium spillover. Russ. J. Bioorganic Chem. 26 (8), 527–531
  54. Kuprianova MA, Zhmak MN, Koroev DO, Chepurkin AV, Volpina OM, Ivanov VT (2000). Synthetic Peptide Constructs on the Basis of Immunoactive Fragments of the A22Strain VP1of the Foot-and-Mouth Disease Virus. Russ. J. Bioorganic Chem. 26 (12), 832–837
  55. Koroev DO, Kotelnikova OV, Volpina OM, Zhmak MN, Kuprianova MA, Agafonova SA, Alliluev AP, Litvinov IS, Nesmeyanov VA, Ivanov VT (2000). Induction of antimeningitis immunity by the synthetic peptides: I. The immunoactive synthetic fragments of porin A from Neisseria meningitidis. Russ. J. Bioorganic Chem. 26 (5), 291–296
  56. Koroev DO, Kotelnikova OV, Volpina OM, Zhmak MN, Kupriyanova MA, Agafonova SA, Alliluev AP, Litvinov IS, Nesmeyanov VA, Ivanov VT (2000). Induction of antimeningitis immunity by the synthetic peptides. I. The immunoactive synthetic fragments of porin a from Neisseria meningitidis. Bioorg Khim 26 (5), 329
  57. Utkin YN, Zhmak MN, Methfessel C, Tsetlin VI (1999). Synthesis of iodinated photoactivatable derivative. Toxicon 37 (12), 1683–1695
  58. Maslennikov IV, Shenkarev ZO, Zhmak MN, Ivanov VT, Methfessel C, Tsetlin VI, Arseniev AS (1999). NMR spatial structure of α-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors. FEBS Lett 444 (23), 275–280
  59. Volpina OM, Surovoy AY, Zhmak MN, Kuprianova MA, Koroev DO, Chepurkin AV, Toloknov AS, Ivanov VT (1999). A peptide construct containing B-cell and T-cell epitopes from the foot- and-mouth disease viral VP1protein induces efficient antiviral protection. Vaccine 17 (6), 577–584
  60. Kasheverov I, Zhmak M, Chivilyov E, Saez-Brionez P, Utkin Y, Hucho F, Tsetlin V (1999). Benzophenone-type photoactivatable derivatives of α-neurotoxins and α- conotoxins in studies on Torpedo nicotinic acetylcholine receptor. J Recept Signal Transduct Res 19 (14), 559–571
  61. Volpina OM, Yarov AV, Zhmak MN, Kuprianova MA, Chepurkin AV, Toloknov AS, Ivanov VT (1996). Synthetic vaccine against foot and mouth disease based on a palmitoyl derivative of the VP1protein 135-159 fragment of the A22virus strain. Vaccine 14 (14), 1375–1380