Зелепукин Иван Владимирович

Аспирант (Лаборатория молекулярной иммунологии)

Эл. почта: ivan.zelepukin@gmail.com


Период обученияСтрана, городУчебное заведениеДополнительная информация
2017 Москва, Россия Московский Физико-Технический Институт

Избранные публикации

  1. Zelepukin I.V., Nikitin M.P., Cherkasov V.R., Nikitin P.I., Deyev S.M., Petrov P.V. (2016). Synthesis of magnetic silica nanomarkers with controlled physicochemical properties. Dokl. Biochem. Biophys. 470 (1), 335–337 [+]

    Magnetic markers which can be detected with an extremely high sensitivity with the method of magnetic particle quantification (MPQ) were synthesized. Using a controlled Stober reaction, a set of magnetic silica markers of different sizes and zeta potentials was obtained. The use of a carboxymethyl dextran polymer to stabilize the magnetite particles during the synthesis made it possible to substantially reduce the detection limit of the obtained construct, which opens up new opportunities for creating effective diagnostic nanoagents.

  2. Shipunova V.O., Nikitin M.P., Zelepukin I.V., Nikitin P.I., Deyev S.M., Petrov R.V. (2015). A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents. Dokl. Biochem. Biophys. 464 (1), 315–8 [+]

    A comprehensive study of the interactions between lectins and glycoproteins possessing different glycosylation profiles in the composition of nanoparticles was carried out in order to find specifically interacting protein pairs for the creation of novel classes of multifunctional nanoagets that based on protein-assisted selfassembly. We obtained information about specific interactions of certain lectins with selected glycoproteins as well as about the ability of certain monosaccharides to competitively inhibit binding of glycoproteins with lectins. These protein-mediated interactions may be involved in the formulation of self-assembled nanoparticles for therapy and diagnostics of various diseases.