FEBS Journal Editor’s choice: the research article about peptide modulator of ASIC1a with a unique structure
Researchers from Laboratory of Neuroreceptors and Neuroregulators and Laboratory of Biomolecular NMR-Spectroscopy of IBCh RAS, together with the Laboratory of Biological Testing of the BIBCh, isolated and characterized Ms13-1, a new peptide of the sea anemone Metridium senile with a unique 3D-structure and a pronounced selective effect on acid-sensing ion channels ASIC1a. Ms13-1 has a spatial fold named the "Cys-ladder" by the authors, and is a member of a novel structural class. In the nanomolar range, Ms 13-1 acts as a positive allosteric modulator of ASIC1a, and the injection of the peptide into the mouse hind paw causes pain, which is suppressed by the selective antagonist of ASIC1. The work was published in the FEBS Journal and was marked as the Editors' choice for the May issue. Learn more
may 29