I was born in Moscow and currently live here permanently. Married.
Education
| Period |
Coyntry, city |
University |
Additional info |
| 1994–1995 |
Japan, Kobe |
Kobe University |
post-doctoral fellowship |
| 1987–1989 |
USSR, Moscow |
Lomonosov Institute of Fine Chemical Technology |
PhD |
| 1979–1984 |
USSR, Moscow |
Moscow Institute of Engeneering Physics |
distinction diploma |
IBCh positions
Titles
| 2026 |
Doctor of Science (Chemistry) |
|
Doctor of Philosophy (Chemistry) |
Skills
I am proficient in optical (IR-, CD-, fluorescence spectroscopy), radiospectroscopy (NMR, ESR) techniques and computational methods (Molecular Dynamics etc.) for studying the structure of membrane-active polypeptides, as well as their interaction with lipid and biomembranes. I have programming skills in Python.
Scientific interests
Membrane active polypeptides: structure and interaction with lipid and biomembranes.
Scientific results
The structural-functional relationships within a series of cytotoxins (CTs) from cobra venom and linear polypeptides (LPs) from spider venom were investigated. The former belong to the three-finger protein family, characterized by four disulfide bonds and beta-sheet fold. The latter lack disulfide bonds; they are disordered in aqueous solution but adopt a fully or partially alpha-helical structure upon interaction with lipid membranes or biomembranes. Based on this research, a doctoral dissertation titled "Membrane-Active Polypeptide Toxins: Structure-Function Relationships" was successfully defended on October 28, 2026. The work includes a method for designing antimicrobial peptides (AMPs) with a specific spectrum of activity, based on fragments of CTs and LPs and utilizing neural networks. Furthermore, the study demonstrates the advantages of employing a combination of high-resolution and broad-line NMR spectroscopy to investigate the mechanism of action of these AMPs.
Scientific societies’ membership
Member of the Biochemical Society of the USSR (then Russia).
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